Publications by authors named "Ahmed Nashaat Alnagar"
Pharm Dev Technol
November 2024
Article Synopsis
- Traditional chemotherapeutic drugs often show limited effectiveness and cause serious side effects in cancer patients, leading researchers to explore alternative treatments like Polydatin (PD), which has promising antitumor properties but suffers from low solubility and bioavailability.
- The study focused on creating specialized nanoparticles (NPs) coated with hyaluronic acid and lactoferrin to enhance the targeting of lung cancer cells, specifically those with CD44 receptors, using a layer-by-layer self-assembly technique.
- Results showed that the developed nanoparticles (HA110/Lf-coated PD/PLGA) demonstrated a favorable size and charge, as well as significantly increased cytotoxicity and cellular uptake, supporting their potential as a targeted therapy for lung cancer.
