Publications by authors named "Ahmed Mughram Alshehri"
Article Synopsis
- MALT1 is a crucial protein involved in immune responses, and its unusual signaling is linked to various diseases, including cancer, making it a target for new therapies.
- The study aimed to identify plant-based small molecules that could bind to MALT1 using computational methods, screening 34 compounds for their effectiveness.
- Cyanidin emerged as a promising allosteric inhibitor of MALT1, showing better binding and stability than the control drug thioridazine, but further testing is necessary to confirm its effectiveness in treating cancer and related diseases.
Chronic myeloid leukemia (CML) is a hematological malignancy characterized by the neoplastic transformation of hematopoietic stem cells, driven by the Philadelphia (Ph) chromosome resulting from a translocation between chromosomes 9 and 22. This Ph chromosome harbors the breakpoint cluster region (BCR) and the Abelson (ABL) oncogene (BCR-ABL1) which have a constitutive tyrosine kinase activity. However, the tyrosine kinase activity of BCR-ABL1 have been identified as a key player in CML initiation and maintenance through c-Abl kinase.
View Article and Find Full Text PDFRepurposing the inhibitors of MMP-9 and SGLT-2 against ubiquitin specific protease 30 in Parkinson's disease: computational modelling studies.
J Biomol Struct Dyn
February 2024
Ubiquitin specific protease 30 (USP30) has been attributed to mitochondrial dysfunction and impediment of mitophagy in Parkinson's disease (PD). This happens once ubiquitin that supposed to bind with deformed mitochondria at the insistence of Parkin, it's been recruited by USP30 the distal ubiquitin binding domain. This is a challenge when PINK1 and Parkin loss their functions due to mutation.
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