Publications by authors named "Ahmed M Mamdouh"
Article Synopsis
- In many cancers, including acute myeloid leukemia (AML), the challenge of relapse often involves multidrug resistance (MDR) linked to changes in cancer cell genetics.
- Researchers employed acute myeloid leukemia patient-derived xenografts (PDX) to explore drug sensitivity and resistance mechanisms, revealing that resistance often correlates with diminished mitochondrial apoptotic priming and affects responses to various drug types.
- Their findings suggest that by using dynamic BH3 profiling (DBP), it's possible to identify effective drugs for patients experiencing drug-resistant relapses, highlighting the potential for this method in developing personalized treatment strategies.
Objective: Malnutrition threatens children worldwide. The objective of the current study was to highlight the role of nutritional screening, evaluate the effectiveness of nutritional intervention program, and whether nutritional supplements have surplus benefit.
Patients And Methods: Screening Tool for the Assessment of Malnutrition in Pediatrics (STAMP) was used to screen 3640 clinically stable 2-5 years old children recruited from the outpatient clinics, Children's Hospital, Ain Shams University.
Aim: Hepatocellular carcinoma (HCC) is a potentially life-threatening cancer. In the current study, anti-HCC efficacy of amygdalin, or metformin alone or in combination in comparison to doxorubicin was studied.
Main Methods: Both in-vitro and in-vivo based models.