In vivo anti-inflammatory and hepatoprotective activities of (Forssk.) aerial parts in relation to its phytomolecules.

A total methanolic extract and its sub-extracts of (Forssk.) aerial parts were subjected to acute toxicity, anti-inflammatory, and hepatoprotective investigations. The methanolic extract was safe upto 3 g/kg on mice.

trachylobane-3-hydroperoxide, a new diterpene from the root bark of (Fam.; Euphorbiaceae).

New trachylobane-3-hydroperoxide together with four known compounds, ricinine , trimethoxy ellagic acid , dimethoxy ellagic acid and aleurotolic acid were isolated from the methylene chloride fraction of the root bark of . The structures of these secondary metabolites were elucidated by using different spectroscopic techniques, H NMR, C NMR, HSQC, HMBC, H-H COSY, NOESY, HR-ESI-MS, EI-MS and comparison with published data. trachylobane-3-hydroperoxide showed moderate cytotoxic activity by MTT assay method against human breast cancer cells (MCF-7) and human hepatocyte-derived carcinoma cells (Huh-7) with IC values of 24.