Publications by authors named "Ahmed M Elsakka"
Article Synopsis
- Glioblastoma (GBM) is the deadliest brain tumor in adults, and current therapies are largely ineffective, which drives the need for new treatment strategies based on the tumor's metabolic needs, specifically glucose and glutamine.
- A ketogenic metabolic therapy (KMT) approach targets these metabolic pathways by combining dietary changes with specific drugs to limit glycolysis and glutaminolysis, while promoting the use of non-fermentable fuels like ketones and fatty acids.
- The glucose-ketone index (GKI) serves as a biomarker to monitor treatment effectiveness, aiming to create a more hostile environment for tumor growth and improve outcomes in GBM as well as potentially other cancer types reliant on similar metabolic pathways.
Article Synopsis
- Glioblastoma (GBM) relies on fermentation metabolism for energy and growth, primarily using glucose and glutamine as fuels while exhibiting mitochondrial defects.
- The fermentation process produces acidic waste products like lactic acid, contributing to drug resistance, tumor invasion, and metastasis, despite existing treatments often exacerbating the acidic microenvironment.
- Restricting glucose and glutamine while increasing non-fermentable ketone bodies may rebalance the microenvironment’s pH and prevent tumor growth in a non-toxic way.
Objectives: To compare the safety and efficacy of bipolar transurethral plasma vaporisation (B-TUVP) as an alternative to the 'gold standard' monopolar transurethral resection of the prostate (M-TURP) for the treatment of benign prostatic hyperplasia (BPH) in a prospective randomised controlled study.
Patients And Methods: In all, 82 patients indicated for prostatectomy were assigned to two groups, group I (40 patients) underwent B-TUVP and group II (42 patients) underwent M-TURP. The safety of both techniques was evaluated by reporting perioperative changes in serum Na, serum K, haematocrit (packed cell volume), and any perioperative complications.
Context: Percutaneous nephrolithotomy (PNL) is traditionally performed with the patient in the prone position.
Objective: To assess the efficacy and safety of the prone and supine positions, particularly in obese patients and in those with staghorn calculi.
Evidence Acquisition: A Medline search was conducted for articles published during the last 10 yr related to PNL in the prone and supine positions.