Publications by authors named "Ahmed M Elgendy"
Objective: Oxidative stress and inflammation play crucial roles in the onset of kidney injury and crystal formation caused by hyperoxaluria. Indapamide is a potent medication for treating renal calculi, but it has severe side effects such as hypokalemia, hypercalcemia, and hyperuricemia. Therefore, it is advisable to explore alternative treatments that do not have these side effects.
View Article and Find Full Text PDFObjectives: To compare autogenous dentin nanoparticles with allograft bone grafts in the treatment of stage III periodontitis.
Method: The randomised study was conducted at the Department of Oral Medicine and Periodontology, Faculty of Oral and Dental Medicine, Kafrelsheikh University Hospital, Egypt, from January 2021 to January 2022, and comprised adult patients of either gender with stage III periodontitis. Each patient's bilateral intrabony defect was randomly treated with an allograft on one side and a graft made of dentin nanoparticles on the testside.
Article Synopsis
- The study explores the relationship between ANGPTL4, HIF-1α, and inflammatory markers (NF-κB/P65 and IL-1β) in breast cancer, focusing on how they may influence cancer progression.
- ANGPTL4 levels were found to be significantly higher in high-grade breast cancer compared to lower grades and controls, indicating a potential role in tumor severity.
- The findings suggest that ANGPTL4, along with HIF-1α and other inflammatory markers, may serve as important signaling factors in the progression of breast cancer.
Pharmaceutical profiling studies were conducted on a novel prototype gamma-secretase inhibitor, to determine the potential of its oral absorption. Such compounds can be of use in the treatment of Alzheimer's disease (AD). The studies included determination of solubility, dissociation constant (pK(a)), octanol/water partition coefficient (log P) and the capacity factor (k'(IAM)) on immobilized artificial membrane (IAM) chromatographic columns.
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