Publications by authors named "Ahmed Khaled Abosalha"
Article Synopsis
- RNA interference (RNAi) using small interfering RNA (siRNA) shows promise for treating genetic disorders but faces significant delivery challenges due to various barriers.
- Strategies to enhance siRNA delivery include chemical modifications, bioconjugation with ligands, and nanotechnology-based systems like liposomes and nanoparticles.
- Despite the established mechanism of siRNA as a gene silencer, effective therapeutic products remain limited, and there's an urgent need for improved delivery systems to target specific sites for treating diseases early on.
Clinical pharmacology of siRNA therapeutics: current status and future prospects.
Expert Rev Clin Pharmacol
November 2022
Introduction: Small interfering RNA (siRNA) has emerged as a powerful tool for post-transcriptional downregulation of multiple genes for various therapies. Naked siRNA molecules are surrounded by several barriers that tackle their optimum delivery to target tissues such as limited cellular uptake, short circulation time, degradation by endonucleases, glomerular filtration, and capturing by the reticuloendothelial system (RES).
Areas Covered: This review provides insights into studies that investigate various siRNA-based therapies, focusing on the mechanism, delivery strategies, bioavailability, pharmacokinetic, and pharmacodynamics of naked and modified siRNA molecules.