Expression Profiles of Integrin-Linked Kinase, Vascular Endothelial Growth Factor A, and Ephrin Type-A Receptor 2 in Colorectal Cancer Lymph Nodes.

Background Colorectal cancer (CRC) is the third most frequently diagnosed cancer globally, with a high incidence of morbidity and mortality. Early diagnosis of CRC is crucial for determining appropriate treatment regimens, thereby prolonging overall survival rates and improving prognostic outcomes. Objectives This study aimed to investigate the expression profiles of specific proteins in the lymph nodes (LNs) of CRC patients, including integrin-linked kinase (ILK), vascular endothelial growth factor A (VEGFA), and ephrin type-A receptor 2 (EphA2), through immunohistochemical studies.

Video-assisted thoracoscopic surgery repair of an idiopathic internal mammary artery aneurysm.

A discussion of an internal mammary artery aneurysm is a rare finding in the literature. This condition can cause serious complications, including haemothorax and pneumo-haemothorax, and can lead to haemorrhagic shock; it can also be fatal. These effects can be explained by the rate of flow of the blood in the internal mammary artery, that is, 150 ml/minute, which leads to a blood loss of one litre in minutes.

Global geoepidemiology of gastrointestinal surgery rates in Crohn's disease.

Background: Data regarding the worldwide gastrointestinal surgery rates in patients with Crohn's disease (CD) remains limited.

Aim: To systematically review the global variation in the rates of surgery in CD.

Methods: A comprehensive search analysis was performed using multiple electronic databases from inception through July 1, 2020, to identify all full text, randomized controlled trials and cohort studies pertaining to gastrointestinal surgery rates in adult patients with CD.

Design of a novel multi-epitope vaccine against Marburg virus using immunoinformatics studies.

Marburg virus (MARV) is a highly contagious and virulent agent belonging to Filoviridae family. MARV causes severe hemorrhagic fever in humans and non-human primates. Owing to its highly virulent nature, preventive approaches are promising for its control.

Effect of Substituting Soybean Meal in Diets with Pumpkin () Seed Cake on Water Quality, Growth, Antioxidant Capacity, Immunity, and Carcass Composition.

A 10-week feeding experiment was performed to determine the impacts of partial substitution of soybean meal (SB) with pumpkin seed cake (PSC) in diets on water quality, growth rate, antioxidant capacity, immunity, and carcass composition. One hundred and fifty tilapia fish (average weight, 11.93 ± 0.

Study of the effect of bezafibrate with ginkgo biloba extracts in an animal model of hepatotoxicity induced by doxorubicin.

This study aimed to evaluate the hepatoprotective effect of combining bezafibrate with ginkgo biloba in doxorubicin-induced hepatotoxicity in rats. Thirty Wister albino rats were allocated into five groups: The negative control group, the positive control group, both received 1 ml of D.W, bezafibrate group received (100 mg/kg), ginkgo biloba group received (60 mg/kg) and the fifth group received bezafibrate + ginkgo biloba.

Experimental validation of rotating detonation for rocket propulsion.

Space travel requires high-powered, efficient rocket propulsion systems for controllable launch vehicles and safe planetary entry. Interplanetary travel will rely on energy-dense propellants to produce thrust via combustion as the heat generation process to convert chemical to thermal energy. In propulsion devices, combustion can occur through deflagration or detonation, each having vastly different characteristics.

Protective role of flavonoids quercetin and silymarin in the viral-associated inflammatory bowel disease: an updated review.

Inflammatory bowel disease (IBD) is a chronic recurrent inflammation of the gastrointestinal tract (GIT). IBD patients are susceptible to various infections such as viral infections due to the long-term consumption of immunosuppressive drugs and biologics. The antiviral and IBD protective traits of flavonoids have not been entirely investigated.

Interaction between Age and Primary Site on Survival Outcomes in Primary GI Melanoma over the Past Decade.

Background: Primary malignant melanomas of the Gastrointestinal mucosa are uncommon. Most cases of gastrointestinal (GI) melanomas are secondary, arising from metastasis at distant sites. The purpose of this study is to assess to what extent the interaction between independent prognostic factors (age and tumor site) of primary GI melanoma influence survival.

Association between Multiple Myeloma and Ulcerative Colitis: A Cross-Sectional Analysis.

Background And Aims: Multiple myeloma (MM) is a plasma cell dyscrasia that is common among patients with autoimmune diseases. However, the association between ulcerative colitis (UC) and multiple myeloma (MM) is yet to be established. We aimed to evaluate the prevalence of MM among patients with UC in the United States.

A Case Report of Acute Severe Necrotizing Pancreatitis following the Johnson & Johnson Vaccine against the Novel SARS-CoV-2.

Acute pancreatitis is an inflammatory condition, which is a leading gastrointestinal cause of hospitalization in the United States. Several conditions are associated with acute pancreatitis. More recently, there have been a few cases reported of acute pancreatitis following the Pfizer-BioNTech COVID-19 mRNA vaccine.

Health Maintenance and Preventative Care in Inflammatory Bowel Disease: A Systematic Review of the Overall Quality of Societal Recommendations.

Background Aims: Preventative care plays an important role in maintaining health in patients with inflammatory bowel disease (IBD). We aimed to assess the overall quality, strength, and transparency of conflicts among guidelines on preventative care in IBD.

Methods: A systematic literature search was performed in multiple databases to identify all guidelines pertaining to preventative care in IBD in April 2021.

Coding-Complete Sequence of Isolated from Iraq.

Here, we report the coding-complete sequence of Cowpea mild mottle virus (CPMMV; strain Hilla) in cowpea using total transcriptome sequencing (RNA-seq) and bioinformatics analyses. The sequence length was 8,119 bp long and has 6 open reading frames. The genome was phylogenetically close to two isolates collected from Ghana.

Drug-Induced Liver Injury from Herbal Liver Detoxification Tea.

The increasing consumption of unregulated herbal and dietary supplements has presented clinicians with new challenges in assessing and managing acute liver injury. Patients may present in various ways ranging from asymptomatic transaminitis to acute liver failure. Several natural products have been found to mitigate drug-induced liver injury, which has led to the creation of numerous registries to outline all its aspects further.

The COVID-19 pandemic and health workforce brain drain in Nigeria.

Over the years, the Nigerian healthcare workforce, including doctors, nurses, and pharmacists have always been known to emigrate to developed countries to practice. However, the recent dramatic increase in this trend is worrisome. There has been a mass emigration of Nigerian healthcare workers to developed countries during the COVID-19 pandemic.

The effect of relative air humidity on the evaporation timescales of a human sneeze.

The present paper investigates droplet and aerosol emission from the human respiratory function by numerical and experimental methods, which is analyzed at the worst-case scenario, a violent sneeze without a face covering. The research findings develop the understanding of airborne disease transmission relevant to COVID-19, its recent variants, and other airborne pathogens. A human sneeze is studied using a multiphase Computational Fluid Dynamics (CFD) model using detached eddy simulation coupled to the emission of droplets that break up, evaporate, and disperse.

Four-Line C*/CH* Optical Sensor for Chemiluminescence Based Imaging of Flame Stoichiometry.

In the present work, an optical sensor was developed and calibrated for the purpose of non-intrusive equivalence ratio measurements in combustion systems. The sensor incorporates a unique four-line, single-sensor chemiluminescence imaging-based approach, which relies on the ratio of C* and CH* radical-species intensities to obtain measurements of equivalence ratios. The advantage of the four-line sensor is the use of additional filtering to mitigate broadband luminescence signals, and its improvements over conventional two-line chemiluminescence diagnostics are discussed.

Human Research Study of Particulate Propagation Distance From Human Respiratory Function.

Background: Airborne viral pathogens like severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can be encapsulated and transmitted through liquid droplets/aerosols formed during human respiratory events.

Methods: The number and extent of droplets/aerosols at distances between 1 and 6 ft (0.305-1.

Single-sensor filter-intensified fiber optic 4D tomographic CH* chemiluminesence flame measurements.

Chemiluminesence is one of the most common reacting flow visualization techniques, in which a narrowband wavelength associated with species radicals is captured on an image sensor. This technique can provide key insights into flame physics, particularly when a full 3D field can be extracted. Tomographic imaging can capture 3D instantaneous information, but becomes impractical to use when the technique is extended to larger, heavier high-speed imaging equipment.

A Suggested Strategy to Integrate an Elective on Clinical Nutrition with Culinary Medicine.

Unlabelled: Time allocated to nutrition education in the medical school curriculum stands in contrast to high mortality rates attributable to poor diet in patients. Counseling patients on nutrition-related diseases is a critical skill for physicians, particularly those entering primary care. The crowded medical school curriculum has made adding hours of nutrition instruction difficult.

Effect of saliva fluid properties on pathogen transmissibility.

With an increasing body of evidence that SARS-CoV-2 is an airborne pathogen, droplet character formed during speech, coughs, and sneezes are important. Larger droplets tend to fall faster and are less prone to drive the airborne transmission pathway. Alternatively, small droplets (aerosols) can remain suspended for long time periods.

Stabilized detonation for hypersonic propulsion.

Future terrestrial and interplanetary travel will require high-speed flight and reentry in planetary atmospheres by way of robust, controllable means. This, in large part, hinges on having reliable propulsion systems for hypersonic and supersonic flight. Given the availability of fuels as propellants, we likely will rely on some form of chemical or nuclear propulsion, which means using various forms of exothermic reactions and therefore combustion waves.

Sternal reconstruction using locking compression plates (LCP): our experience in Egypt, a case series.

Background: Sternal fractures are rare accounting for about 3-8% of traumatic chest. There are many lines of treatments for sternal fractures which can be classified as conservative or surgical. Surgical techniques include wire fixation and sternal plating.

The Anti-Inflammatory Effect of Different Doses of Aliskiren in Rat Models of Inflammation.

Objective: The present study was designed to evaluate the anti-inflammatory effects of different doses of aliskiren in two animal models of inflammation.

Methodology: Sixty-six Wistar rats were allocated into five groups: the first group (six rats) was treated with the vehicle only, without induction of paw edema and granulomatous inflammation, and served as a negative control; the second group (12 rats) was allocated into two subgroups and treated with the vehicle only, with induction of paw edema and granulomatous inflammation, and served as a positive control; the third group (36 rats) was allocated into six subgroups and treated with different doses of aliskiren (15, 30, and 60 mg/kg) in both models; the fourth group (12 rats) was treated with dexamethasone (1 mg/kg) in both models of inflammation. Serum concentrations of tumor necrosis factor-α (TNF-α), interleukin-10 (IL-10), vascular cell adhesion molecule-1 (VCAM-1), and high sensitivity C-reactive protein (hs-CRP) were measured.

The Use of Topical Nitroglycerin to Facilitate Radial Arterial Catheter Insertion in Children: A Randomized Controlled Trial.

Objectives: To determine whether the use of topical nitroglycerin patch increases radial artery diameter and facilitate cannulation in children.

Design: Randomized controlled trial.

Setting: Cairo University Hospital.