RP-UHPLC-ESI-QTOF-MS analyses and evaluation of the antioxidant, antimicrobial, anti-diabetic and anti-Alzheimer activities of Desf.

The polyphenolic compounds of the -butanol fraction of Desf. (BFLTe) were characterised by RP-UHPLC-ESI-QTOF-MS analyses with the main presence of 6,8-di--glucosyl naringenin (11.7%), vicenin 2-isomer 2 (8.

Phytochemical study, antioxidant and tyrosinase inhibitory activities of Maire.

Chemical investigation of the aerial parts of Maire led to the isolation and identification of one sesquiterpene lactone glucoside of the guaianolide type (dihydropseudoivalin-4---d-glucopyranoside), along with nine known compounds including one diterpenoid, two sesquiterpenoids, three lignanes and three flavonoids. Their structures were established on the basis of spectroscopic analysis. All these compounds were evaluated for their DPPH radical scavenging and tyrosinase inhibitory activities.

RP-UHPLC-ESI-QTOF-MS analyses, antioxidant, antimicrobial, analgesic activities and toxicity of All.

Fourty five polyphenols were identified in the hydroethanol extract of All. by LC-HRMS/MS with caffeoyl-6-oleside (5.74%), eucommin A (4.

A new acylated flavonol triglycoside and evaluation of the antioxidant activity of subsp. (Murb.) Emb. & Maire.

A new acylated flavonol triglycoside, quercetin-3--(5'--hydroxybenzoyl)-β-D-apiofuranosyl-(1→2)[α-L-rhamnopyranosyl-(1→6)]-β-D-galactopyranoside (), was isolated from the aerial parts of subsp. (Murb.) Emb.

Biological activities and polyphenolic profile of (L.) L.

The -butanol extract of (L.) L. aerial parts (BESA) was analysed by LC-HRMS/MS.

A new triterpene saponin and known compounds from the polar extract of L. and evaluation of their antioxidant activity.

A new triterpene saponin, 2, 3, 21, 23-tetrahydroxyolean-12-en-28-oic-acid-28--β-D- glucosyl-(2''→1')-β-D-glucoside (), was isolated from the -butanol extract of dried aerial parts of L. (Lamiaceae) in addition to two known flavonoids, apigenin 7--β-D-glucoside (), threo-guaiacylglycerol 3--[6---hydroxybenzoyl]-β-D-glucoside (), luteolin 7--β-D-glucoside (), verbascoside () and rosmarinic acid (). The structure elucidation of these compounds was based on analyses of spectroscopic data including 1D-, 2D-NMR and HR-ESI-MS techniques and by comparing their NMR data with those reported in the literature.

Triterpenoid saponins from Anagallis monelli ssp. linifolia (L.) Maire and their chemotaxonomic significance.

Thirteen undescribed triterpenoid saponins named monellosides A-M, were isolated from the aerial parts of Anagallis monelli ssp. linifolia (L.) Maire, together with ten known oleanane-type glycosides.

Triterpene saponins from Silene gallica collected in North-Eastern Algeria.

Eleven previously undescribed triterpene saponins, named silenegallisaponin A-K (1-11), were isolated from the aerial parts of Silene gallica L. Their structures were elucidated by analysis of 1D and 2D-NMR spectroscopic data and mass spectrometry (HR-ESI-MS). The saponins comprised caulophyllogenin, echinocystic acid, or quillaic acid substituted at C-3 by a β-d-glucuronic acid or β-d-galactopyranosyl-(1 → 3)-β-d-glucuronopyranoside and at C-28 by a β-d-fucopyranose substituted at C-2 by a β-d-glucose and at C-3 by a β-d-glucose or a β-d-quinovose.

Triterpenes from Salvia argentea var. aurasiaca and their antibacterial and cytotoxic activities.

Five undescribed ursane-type triterpenes, identified as 1β,3β,15α-trihydroxy-urs-9(11)-12-diene (1), 1β,3β,15α,28-tetrahydroxy-urs-9(11),12-diene (2), 1β,3β-dihydroxy-urs-9(11),12-dien-28-al (3), 1β,3β,7β,15α,28-pentahydroxy-urs-12-ene (4), and 1β,3β,15α-trihydroxy-urs-11-en-28-al (5), together with five known compounds (6-10), were isolated from the acetone extract of the dried aerial parts of Salvia argentea L. var. aurasiaca (Pomel) Batt.

Phytochemistry and Antioxidant Activity of Aerial Parts of Phagnalon sordidum L.

One new natural monoterpene, 5---d-glucopyranosyl-2-hydroxy--cymene (1: ), and 11 known compounds were isolated through a biologically oriented approach from the aerial parts of L. The most active extract and fractions were selected using 3 complementary antioxidant activity assays. Results and the different methods were compared by relative antioxidant capacity index.

Guaianolides from Ormenis mixta: Structural Insights and Evaluation of Their Anti-inflammatory Profile.

In this paper, the isolation of five new guaianolides (1:  - 5: ) and four (6:  - 9: ) known sesquiterpenes from aerial parts is reported. The structural determination of the guaianolides was obtained by NMR spectroscopic data, as well as MS experiments. Their relative configurations were assigned by a combined quantum mechanical/NMR approach, comparing the experimental C/H NMR chemical shift data and homonuclear coupling constants with the related predicted values.

Chemical composition and biological potential of Boiss. & Reut. essential oil.

The fresh aerial parts of Boiss. & Reut. (syn.

6"'--acetylisospinosin, a new -glycosylflavone and known compounds from the aerial parts of .

A new -glycosylflavone, identified as 6"'--acetylisospinosin (1), was isolated from the aerial parts of together with 30 known compounds. The structures of these compounds were established by interpretation of their spectral data, mainly UV, 1D and 2D NMR spectroscopic methods including (H and C NMR, COSY, ROESY, HSQC and HMBC experiments), ESI-MS, and by comparison with the literature data.

Triterpenoid saponins from Scabiosa stellata collected in North-eastern Algeria.

Eight undescribed triterpenoid saponins, scabiostellatosides A-H, together with three known compounds were isolated from the whole plant of Scabiosa stellata L. Their structures were established by spectroscopic analyses (1D, 2D-NMR and HRESIMS) and chemical methods. Scabiostellatosides A-H were evaluated for their cytotoxicity against human fibrosarcoma cell line (HT1080).

Two new bis-iridoids isolated from Scabiosa stellata and their antibacterial, antioxidant, anti-tyrosinase and cytotoxic activities.

This study presents the chemical profile investigation of a 70% ethanol extract obtained from Scabiosa stellata, a medicinal herbaceous traditionally used to treat heel cracks. A C NMR-based dereplication methodology was firstly applied on centrifugal partition chromatography-generated fractions in order to quickly identify the major compounds of the extract. The dereplication process was then completed by semi-preparative high-performance liquid chromatography in order to identify unknown or minor compounds.

Flavonoids, cytotoxic, antioxidant and antibacterial activities of Evax pygmaea.

Context: Phytochemical study and biological potential of Evax pygmaea (L.) Brot. (Asteraceae) are reported for the first time.

A new 2-alkylhydroquinone glucoside from Phagnalon saxatile (L.) Cass.

A new 2-alkylhydroquinone glucoside, 1-O-β-d-glucopyranosyl-1,4-dihydroxy-2-((E) 2-oxo-3-butenyl)benzene (1), in addition to nine known compounds were isolated from the aerial parts of Phagnalon saxatile (L.) Cass. (Asteraceae).

Antibacterial, antioxidant and cytotoxic activities of triterpenes and flavonoids from the aerial parts of Salvia barrelieri Etl.

From the aerial parts of Salvia barrelieri Etl. (Lamiaceae), 12 compounds including a new triterpene, 3β-acetoxy-olean-18-ene-2α-ol, were isolated. Their structures were established by the combination analyses of spectroscopy including 1D-, 2D-NMR and HRESIMS and in comparison with the reported data in the literature.

Oleanane-type triterpene saponins from Calendula stellata.

Five previously undescribed bisdesmosidic triterpenoid saponins named calendustellatosides A-E, along with fifteen known compounds were isolated from the 70% ethanol whole plant extract of Calendula stellata Cav. (Asteraceae). Their structures were determined by 1D- and 2D-NMR spectroscopy as well as high resolution mass spectrometry and acid hydrolysis.

Chemical composition and antioxidant activity of aerial parts of Ferula longipes Coss. ex Bonnier and Maury.

This is the first study on the phytochemistry and antioxidant activity of Ferula longipes Coss. ex Bonnier and Maury (Apiaceae). A new flavonoid quercetin-3-O-α-L-rhamnopyranoside-7-O-ß-D-[2-O-caffeoyl]-glucopyranoside (1), along with 10 known compounds kaempferol-3-O-α-L-rhamnopyranoside (2), quercetin-3-O-α-L-rhamnopyranoside (3), kaempferol-3-O-ß-D-glucopyranoside-7-O-α-L-rhamnopyranoside (4), isorhamnetin-3-O-α-L-rhamnopyranoside-7-O-ß-D-glucopyranoside (5), quercetin-3-O-α-L-rhamnopyranoside-7-O-ß-D-glucopyranoside (6), isorhamnetin-3,7-di-O-β-D-glucopyranoside (7), apigenin (8), apigenin-7-O-ß-D-glucopyranoside (9), 3,5-dicaffeoylquinic acid (10), deltoin (11) were isolated from the aerial parts of Ferula longipes Coss.

Chemical composition, antioxidant and antibacterial activities of Tamarix balansae J. Gay aerial parts.

A previously undescribed phenolic sulphate ester, potassium 34-dihydroxy-3-methoxybenzoic acid methyl ester-5-sulphate (1), along with nine known flavonoids, kaempferol-3-O-potassium sulphate-4',7-dimethyl ether (2), kaempferol-4',7-dimethyl ether (3), rhamnocitrin-3-O-potassium sulphate (4), rhamnocitrin (5), kaempferol (6), quercetin (7), afzelin (8), quercetin-3-O-α-l-rhamnopyranoside (9) and luteolin-3'-O-potassium sulphate (10) were isolated from the aerial parts of Tamarix balansae. Structures elucidation was performed by comprehensive 1D and 2D NMR analyses, mass spectrometry and by comparison with literature data. The antibacterial assay against Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli and Pseudomonas aeruginosa bacteria showed a good activity for 2, 3, 7 and 9, with MICs ranging from 62.

Antioxidant Flavonoids from Asteriscus maritimus.

One new flavonol glycoside, patuletin-7-Ο-[6-Ο-caffeoyl-2-Ο-[(S)-3-hydroxyisobutanoyl]glucopyranoside] (astermaritimoside) (1) and four known flavonoids, patuletin-7-Ο-β-[-6-Ο-[(S)-3-hydroxyisobutanoyl]glucopyranoside] (2), patuletin-7-Ο-[6-Ο-caffeoylglucopyranoside] (3), patuletin-7-Ο-β-D- glucopyranoside (4) and quercetin-3-Ο-β-rutinoside (5) have been isolated from Asteriscus maritinus (L.) Less. Chemical structures were elucidated by mass spectrometric, and ¹H NMR, ¹³C NMR, COSY, HMQC and HMBC spectroscopic techniques.

Isolation and characterisation of cytotoxic compounds from Euphorbia clementei Boiss.

A new phorbol-type diterpene ester, 4,20-dideoxy-4α-phorbol-12β-acetate-13α-isobutyrate, in addition to 11 known compounds were isolated from the latex and roots of Euphorbia clementei Boiss. Structure elucidation was performed by comprehensive 1D and 2D NMR analyses (H and C NMR, COSY, ROESY, HSQC and HMBC experiments), mass spectrometry (HR-ESI-MS) and by comparison with literature data. The inhibitory activity of all isolated compounds was evaluated against promyelocytic leukemia HL60 and human erythromyeloblastoid leukemia K562 cell lines and seven of these compounds exhibited a weak cytotoxicity with IC values ranging from 40 to 97 μM.

A New Cardenolide and Other Compounds from Salsola tetragona.

One new cardenolide, 3-O-β-D-allopyranosylcoroglaucigenin (salsotetragonin) (1), was isolated from the aerial parts of Salsola tetragona Delile with four known cardenolides (2-5); two known flavonoids (6-7), three known phenolic compounds (8-10) and two known fatty acids (11-12). Their structures were identified by spectroscopic analyses and by comparison of their spectral data with those reported in the literature. Compounds 1-5, 7, 10 and 12 were isolated from the genus Salsola for the first time.

Antioxidant, anticholinesterase and antibacterial activities of Stachys guyoniana and Mentha aquatica.

Context: Stachys guyoniana Noë ex. Batt. and Mentha aquatica L.