Metformin alters peripheral blood mononuclear cells (PBMC) senescence biomarkers gene expression in type 2 diabetic patients.

Background: Although there is increasing evidence showing that cell senescence is increased in circulating PBMC in type 2 diabetes mellitus (T2DM), the data are contradictory. This study examined several senescence biomarkers, including LMNA/C transcript variants, p16, p53, and p21, in PBMC of T2DM patients and the effect of Metformin on these senescence markers.

Methods: Blood samples were obtained from 30 lean, 30 obese, 20 newly diagnosed type 2 diabetes mellitus (T2DM), and 30 T2DM on Metformin.

Effect of aging treatment on the damping capacity and mechanical properties of Mg-6Al-1Zn alloy.

The damping capacity and mechanical properties of Mg-6Al-1Zn alloy after heat treatment were investigated. The damping characteristics of un-heat-treated, solution treated, and aged Mg-6Al-1Zn specimens were determined by measuring the damping ratio and the logarithmic decrement of free vibrations of a bending beam clamped at one side. The microstructural evaluations confirmed that the β-Mg17Al12 phase was reprecipitated after aging and increased with an increase in aging time.