Publications by authors named "Ahmed I El-Batal"

VEGFR2 inhibition has been established as a therapeutic approach for managing cancer. A series of curcumin-based analogues were designed, synthesized, and screened for their anticancer activity against MCF-7 and HepG-2 cell lines and WISH normal cells. Compounds 4b, 4d, 4e, and 4f showed potent cytotoxicity against MCF-7 with IC values of 0.

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Background: Antimicrobial resistance has emerged as a major global health threat, necessitating the urgent development of new antimicrobials through innovative methods to combat the rising prevalence of resistant microbes. With this view, we developed three novel nanoconjugates using microbial natural pigment for effective application against certain pathogenic microbes.

Results: A natural red pigment (RP) extracted from the endophyte Monascus ruber and gamma rays were applied to synthesize RP-ZnO, RP-CuO, and RP-MgO nanoconjugates.

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Article Synopsis
  • - This study introduces a new treatment for vaginal infections caused by Candidiasis using a silver secnidazole nano-hybrid emulsion (Ag-Secn-NHE) combined with probiotics, showing better antifungal properties compared to traditional treatments.
  • - Researchers found that Ag-Secn-NHE-based probiotics, particularly when mixed with Saccharomyces cerevisiae, demonstrated significant antifungal effects against resistant strains like Candida auris and Cryptococcus neoformans, achieving lower minimum inhibitory concentrations (MIC) than free Ag-Secn-NHE.
  • - The study also revealed that Ag-Secn-NHE-based probiotics effectively inhibit biofilm formation (75% against C. auris) and cause noticeable cellular damage to the fungi, confirming their
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Dermatophytosis is a critical sort of skin infection caused by dermatophytes. The long-term treatment of such skin infections may be improved through the application of nanotechnology. This study aimed to prepare griseofulvin zinc Nanohybrid emulsion (GF-Zn-NHE) to improve griseofulvin activity against dermatophytes and some opportunistic pathogenic yeasts and bacteria.

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In this work, gamma irradiation was used to create bimetallic silver‑copper oxide nanoparticles (Ag-CuO NPs) in an ecologically acceptable way using gum Arabic (GA) polymer as a capping and reducing agent. Bimetallic Ag-CuO NPs were investigated through UV-Vis. spectroscopy, HR-TEM, SEM, DLS, and XRD examinations.

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Helicobacter pylori (H. pylori) is the main cause of gastric diseases. However, the traditional antibiotic treatment of H.

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A new series of 4-((7-methoxyquinolin-4-yl) amino)--(substituted) benzenesulfonamide was synthesized via the reaction of 4-chloro-7-methoxyquinoline with various sulfa drugs. The structural elucidation was verified based on spectroscopic data analysis. All the target compounds were screened for their antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and unicellular fungi.

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Recently nanocomposites have become a super-growth inducers as well as vital antifungal agents, which enhance plant growth and suppress plant diseases. A new strategy regarding the fabrication of humic acid (H) and boron (B) conjugated FeO nanocomposites was performed. FeO NP-B and FeO NP-H were synthesized in the presence of gamma-rays (as a direct reducing agent).

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The rise of the highly lethal severe acute respiratory syndrome-2 (SARS-2) as corona virus 2019 (COVID-19) reminded us of the history of other pandemics that happened in the last century (Spanish flu) and stayed in the current century, which include Severe-Acute-Respiratory-Syndrome (SARS), Middle-East-Respiratory-Syndrome (MERS), Corona Virus 2019 (COVID-19). We review in this report the newest findings and data on the origin of pandemic respiratory viral diseases, reservoirs, and transmission modes. We analyzed viral adaption needed for host switch and determinants of pathogenicity, causative factors of pandemic viruses, and symptoms and clinical manifestations.

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The current study aims to evaluate the possible neuroprotective impact of gold nanoparticles (AuNPs) and an alpha-lipoic acid (ALA) mixture against brain damage in irradiated rats. AuNPs were synthesized and characterized using different techniques. Then, a preliminary investigation was carried out to determine the neuroprotective dose of AuNPs, where three single doses (500, 1000, and 1500 µg/kg) were orally administrated to male Wistar rats, one hour before being exposed to a single dose of 7Gy gamma radiation.

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Taxol production by fungi is one of the promising alternative approaches, regarding to the natural and semisynthetic sources; however, the lower yield and rapid loss of Taxol productivity by fungi are the major challenges that halt their further industrial implementation. Thus, searching for fungal isolates with affordable Taxol-production stability, in addition to enhance its anticancer activity via conjugation with gold nanoparticles, is the main objectives of this study. Twenty-four endophytic fungal isolates were recovered from the barks, twigs, and leaves of jojoba plant, among these fungi, Aspergillus flavus MW485934.

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Preparation of a thin film of polyvinyl alcohol (PVA)/myrrh natural resin using a low gamma irradiation dose (1 kGy) was investigated towards increasing the post-harvest time of lemon fruit. Different analytical techniques, such as Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), energy-dispersive X-ray (EDX) spectroscopy, and mapping techniques were used to characterize the prepared thin film. This investigation was carried out to evaluate the effect of different concentrations of myrrh as an edible coating in prolonging shelf life and preserving the quality of lemon fruits ().

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Magnesium ferrite nanoparticles (Mg FeO NPs) was synthesized by a chemical co-precipitation method and characterized via structural and optical properties. The surface of Mg FeO NPs was stabilized with citric acid (CA) by a direct addition method (CA-Mg FeO NPs), then Amoxicillin (AX) was loaded with CA-Mg FeO nanocomposites. Furthermore, their antimicrobial, and antibiofilm activities, growth curve, and effect of UV-illumination methods were examined against different pathogenic microbes.

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Article Synopsis
  • Breast cancer (BC) is a major global health challenge due to its complex nature and late-stage symptoms, leading to difficulties in treatment with current options often lacking specificity and causing side effects.
  • This study introduces a novel delivery system using dual drug-loaded nanoparticles targeting CD44 and folate receptors, designed to improve localized chemo-radiotherapy for BC by enhancing drug selectivity and effectiveness.
  • The findings indicate that these nanoparticles can effectively suppress cancer growth and improve radiotherapy by modulating crucial metabolic pathways and inducing cancer cell death, showcasing their potential as a new treatment strategy for breast cancer.
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Article Synopsis
  • - This study explores the effects of ebselen (Eb) and cerium nanoparticles (ZnCeFeO) on human breast and colon cancer cell lines, focusing on their antimicrobial, antibiofilm, and anticancer properties.
  • - Results showed that ZnCeFeO effectively inhibited the growth of various bacteria and fungi, leading to cell lysis and reduced biofilm formation, indicating strong antimicrobial activity.
  • - Combining Eb with ZnCeFeO and γ-radiation enhanced anti-cancer effects, improving cellular oxidative balance and reducing inflammation, which could lead to new therapeutic strategies for cancer treatment and microbial infections.
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Twenty-eight fungal endophytes were recovered from the different parts of and screened for their Taxol producing potency. Among these isolates, AUMC14487 was reported as the potent Taxol producer (90.53 μg/l).

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Aqueous glutathione selenium nano-incorporation (GSH-SeN-Inco) was prepared by gamma radiation in presence of microbial glutathione (GSH) and selenium dioxide. The novel prepared GSH-SeN-Inco are validated by UV-vis spectroscopy, TEM (17.5 nm), DLS, XRD, EDX and FTIR spectrum reveals the presence of GSH moiety that coating the selenium nanoparticles (SeNPs) forming GSH-SeN-Inco.

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A new strategy regarding the fabrication of chitosan (CS) or ethylene diamine tetraacetic acid (EDTA) on graphene oxide (GO) was performed. The nematocidal potential against Meloidogyne incognita causing root-knot infection in eggplant was tested. The plant immune response was investigated through measuring the photosynthetic pigments, phenols and proline contents, oxidative stress, and antioxidant enzymes activity.

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Different ancillary immunodiagnostic tests were traditionally-established for diagnosis of bovine tuberculosis (BTB) either cellular or humoral as tuberculin skin test (TST), gamma interferon (INF-γ), and indirect enzyme-linked immunosorbent assay (iELISA). These tests had been consumed more time and expensive, and needed sophisticated equipment. To dissolve these problems, serological diagnosis depending on humoral immunity is the aim of this work.

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In this research, irradiation by gamma rays was employed as an eco-friendly route for the construction of bimetallic silver-gold nanoparticles (Ag-Au NPs), while Gum Arabic polymer was used as a capping agent. Ag-Au NPs were characterized through UV-Vis., XRD, EDX, HR-TEM, FTIR, SEM/mapping and EDX analysis.

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To obtain the synergistic antimicrobial potential of nano-composites conjugated with graphene oxide (GO), an alternative approach was developed throughout the hybridization of chitosan (CS) or ethylene diamine tetraacetic acid (EDTA) with GO. The synthesized GO-nanocomposites were identified by XRD, HRTEM, SEM, FTIR, Zeta potential, and Raman spectroscopy. The antimicrobial activity of GO, GO-CS, and GO-EDTA was investigated against some pathogenic bacteria and Candida sp.

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Water scarcity is now a serious global issue resulting from population growth, water decrease, and pollution. Traditional wastewater treatment plants are insufficient and cannot meet the basic standards of water quality at reasonable cost or processing time. In this paper we report the preparation, characterization and multiple applications of an efficient photocatalytic nanocomposite (CoNiFeO; x = 0.

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The novelty of the present research is the synthesis of bismuth oxide nanoparticles (BiO NPs) loaded with the antifungal nystatin drug gamma rays for increased synergistic antimicrobial potential against some pathogenic bacteria and species. The full characterization of the synthesized BiO NPs-Nystatin was achieved by XRD, FT-IR, HR-TEM, and SEM/EDX mapping techniques in order to analyze the crystallinity, chemical functional groups, average particle size, morphology, and elemental structure, respectively. The antimicrobial activities of BiO NPs-Nystatin were examined against pathogenic bacteria and species, including the zone of inhibition (ZOI), minimum inhibitory concentration (MIC), and antibiofilm activity.

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In this paper, we report a layer-by-layer approach for the preparation of a concentric recyclable composite (Co Ni FeO/SiO/TiO; = 0.9) designed for wastewater treatment. The prepared composite was investigated by X-ray diffraction spectroscopy, high-resolution transmission electron microscopy and scanning electron microscopy (SEM) supported with energy dispersive X-ray (EDX) spectroscopy to analyze crystallinity, average particle size, morphology and elemental composition, respectively.

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The novelty of the present work looks in the synthesis of aqueous dispersed selenium nanoparticles (Se NPs) using gamma rays with the aid of various natural macromolecules such as citrus pectin (CP), sodium alginate (Alg), chitosan (CS) and aqueous extract of fermented fenugreek powder (AEFFP) using Pleurotus ostreatus for investigating their impact in vitro toward carcinoma cell. The synthesized Se NPs were characterized by XRD, UV-Vis., DLS, HRTEM, SEM, EDX and FTIR.

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