Intraperitoneal Injection of the Outer Membrane Vesicle (OMV) Stimulated Expressions of Neuroinflammatory Markers and Histopathological Changes in the Brains of Adult Zebrafish.

is the major pathogenic bacteria found in the subgingival plaque of patients with periodontitis, which leads to neuroinflammation. The bacteria destroy periodontal tissue through virulence factors, which are retained in the bacteria's outer membrane vesicles (OMV). This study aimed to determine the real-time effect of an intraperitoneal injection of OMV on the production and expression of inflammatory markers and histopathological changes in adult zebrafishes' central nervous systems (CNS).

Predicting Key Genes and Therapeutic Molecular Modelling to Explain the Association between () and Alzheimer's Disease (AD).

The association between () and Alzheimer's disease (AD) remains unclear. The major aim of this study was to elucidate the role of genes and molecular targets in -associated AD. Two Gene Expression Omnibus (GEO) datasets, GSE5281 for AD (n = 84 Alzheimer's, n = 74 control) and GSE9723 (n = 4 , n = 4 control), were downloaded from the GEO database.