Anti-asthmatic and antioxidant activity of flavonoids isolated from Mentha longifolia subspecies typhoides (Briq.) Harley. and Mentha longifolia subspecies schimperi (Briq.) Briq. on ovalbumin-induced allergic asthma in mice: In-vivo and in-silico study.

Ethnopharmacological Relevance: Mentha longifolia L. has been employed to treat cough, lung inflammation, and bronchial asthma disorders.

Aim Of The Study: Our study was carried out to investigate the medicinal effect of the flavonoids derived from M.

Predictors of short-term mortality in cardiogenic shock: insights from an Egyptian multicenter registry.

Background: Cardiogenic shock (CS) remains a major cause of morbidity and mortality, particularly in developing countries where there are limited resources and a lack of data on CS outcomes. This study aimed to investigate 30-day all-cause mortality in Egyptian patients with CS at tertiary referral centers.

Results: This prospective, observational multicenter registry analyzed 16,681 patients from six cardiac centers, to evaluate the incidence, causes and predictors of CS-related mortality.

Flexural Properties of Periodic Lattice Structured Lightweight Cantilever Beams Fabricated Using Additive Manufacturing: Experimental and Finite Element Methods.

Lattice structures are a type of lightweight structure that is more commonly being applied to engineering systems as a way to reduce mass and enhance mechanical properties. The cantilever beam case is one of the primary modes of loading in many engineering applications, where light-weighting is also crucial. However, lightweight lattice structured cantilever beams have not been investigated considerably due to design and manufacturing limitations.

A Framework for Developing a Multidisciplinary Approach to Prone Positioning in Acute Respiratory Distress Syndrome.

Prone position ventilation (PPV) is one of the few interventions with a proven mortality benefit in the management of acute respiratory distress syndrome (ARDS), yet it is underutilized as demonstrated by multiple large observational studies. Significant barriers to its consistent application have been identified and studied. But the complex interplay of a multidisciplinary team makes its consistent application challenging.

A Review Article on 5-Oxoproline Induced High Anion Gap Metabolic Acidosis.

In 1989, an acquired high anion gap metabolic acidosis due to elevated 5-oxoproline (pyroglutamic acid) was first reported. This is related to chronic acetaminophen use in malnourished patients and women with chronic medical conditions, it could happen even using therapeutic or low doses. The mainstay of treatment is cessation of acetaminophen use along with the administration of intravenous fluids.

Brief Review of Chylothorax Diagnosis and Management: Making the Case for Substance Over Appearance.

Chylothorax is the presence of a chylous effusion in the pleural space. Diagnosing chylothorax requires a high clinical suspicion, awareness of the different appearances of a chylothorax and the performance of tests on the pleural fluid, additional to those typically required to differentiate an exudate from a transudate based on Light's criteria. Chylothorax is a more common diagnosis in the trauma and post-surgical patients, but it is still important for practitioners of other disciplines to be aware of it.

Inadvertent Nasogastric Tube Placement into the Left Bronchial Tree.

Nasogastric tube insertion is a routine procedure that is utilized on a daily basis in our hospitals and long-term care facilities. Blind insertion of these tubes is usually performed by nurses, residents and other health care providers. In this report, we present an incident of misplacement of the nasogastric tube into the bronchial tree causing parenchymal injury and pneumothorax.

Portosystemic Shunt Leading to Encephalopathy in a Non-Cirrhotic Patient.

While portal-systemic encephalopathy is a common entity in cirrhotic patients, it is less frequent in non-cirrhotic patients. We are reporting a case of a 68-year-old female who presented with unresponsiveness for the second time in six months. She underwent extensive evaluation for liver disease with ultrasonography and computerized tomography of the abdomen, testing for causes of liver disease including testing for viral hepatitis was negative.

Chylothorax as a complication of extensive spontaneous left arm DVT.

We present a case of right sided chylothorax in the setting of cirrhosis believed to be secondary to extensive venous thromboembolism of the left upper extremity and exacerbated by chylous ascites. Our patient responded to conservative management with anticoagulation and a repeat thoracentesis revealed transformation of the fluid back to straw coloured transudate. We also include a brief discussion of the diagnosis and management of chylothorax.

Concurrent fusobacterial pyogenic liver abscess and empyema.

We present a very rare case of concurrent empyema and liver abscess caused by Fusobacterium. Our patient presented with 3-month history of subtle abdominal discomfort and cough leading to eventually presenting with marked chest pain, dyspnoea and septic shock. CT revealed a liver abscess and large right-sided pleural effusion.

Extensive Bilateral Nodular Lung: A Diagnostic Challenge.

An elderly female presented to the emergency department with a two-month history of dyspnea on exertion and productive cough. Imaging revealed miliary nodular pattern involving both lungs. She underwent extensive work up evaluating different possible pathological processes.

Pulmonary Hypertension: Brief Review Article.

Pulmonary hypertension (PH) is defined as mean pulmonary artery pressure (mPAP) 25 mmHg or greater at rest; this measurement is obtained during right heart catheterization. The exact prevalence of PH in the U.S.

genotype, physician prescribing pattern, and risk for long QT on serotonin selective reuptake inhibitors.

To examine the impact of  genotype on selective serotonin reuptake inhibitor (SSRI) prescribing patterns. : Observational cohort containing 507 unique individuals receiving an SSRI prescription with genotype already in their electronic medical record. Genotype was distributed as follows: n = 360 (71%) had no loss of function alleles, 136 (26.

A Brief Review of Left Ventricular Assist Devices and Their Management.

The number of people older than 65 will double by 2060, and with it, the number of people suffering from heart failure will also surge. In the United States, it is estimated that there are close to 250,000-500,000 endstage/ advanced heart failure cases. Mechanical circulatory support (MCS) is an evolving advanced therapy for end-stage heart failure.

Antiproliferative activity of stilbene derivatives and other constituents from the stem bark of L.

The antiproliferative activities of 2',3,4',5,5'-pentahydroxy--stilbene , resveratrol , oxyresveratrol , norartocarpetin , kuwanon C , morusin , cudraflavone A, kuwanon G , albafuran C , mulberrofuran G , 3-acetyl-α-amyrin , 3-acetyl--β-amyrin ursolic acid-3--acetate and uvaol , previously identified from the barks of L., were investigated against HepG2 and MCF-7 cell lines. In addition, a series of methylated stilbenes were prepared using compounds - and their antiproliferative effects were similarly investigated.

Epidemiology and clinical outcomes of viral central nervous system infections.

Background: Central nervous system (CNS) viral infections are an important cause of morbidity and mortality. No data are available regarding their epidemiology in Qatar.

Design: We retrospectively evaluated all cerebrospinal fluid findings from January 2011-March 2015 at Hamad Medical Corporation.

Viral infections of the central nervous system in Qatar: epidemiology, pathogenesis and clinical outcomes.

Introduction: Virus-induced diseases of the central nervous system (CNS) represent a significant burden to human health worldwide. They are common causes of morbidities and mortality. There are no previous epidiomologic studies about viral CNS infections done in Qatar or in the Gulf region.

Maternal and Fetal Outcomes in Pregnant Women with a Prosthetic Mechanical Heart Valve.

Background: Pregnancy is associated with several cardiocirculatory changes that can significantly impact underlying cardiac disease. These changes include an increase in cardiac output, sodium, and water retention leading to blood volume expansion, and reductions in systemic vascular resistance and systemic blood pressure. In addition, pregnancy results in a hypercoagulable state that increases the risk of thromboembolic complications.

A new pregnane glycoside from Gomphocarpus fruticosus growing in Egypt.

Phytochemical investigation of Gomphocarpus fruticosus (L.) Ait. of Egyptian origin afforded the new pregnane glycoside lineolon-3-O-[β-D-oleandropyranosyl-(1-4)-β-D-cymaropyranosyl-(1-4)-β-D-cymaropyranoside], along with six known compounds.

Assessment of some Herbal Drugs for Prophylaxis of Peptic Ulcer.

Aqueous (hydrophilic) and chloroform (Lipophilic) extracts of nine medicinal plants currently used in Egyptian traditional medicine to treat some gastrointestinal tract (GIT) disorders were tested for their gastro-protective effect against the incidence of peptic ulcer. Indomethacin-induced ulcer in a rat model was used for this testing. Mentha microphylla, Brassica oleracea Capitata (Cabbage), B.

A new antioxidant stilbene and other constituents from the stem bark of Morus nigra L.

A new stilbene, 2',3,4',5,5'-pentahydroxy-cis-stilbene (1), along with 13 known compounds, resveratrol (2), oxyresveratrol (3), norartocarpetin (4), kuwanon C (5), morusin (6), cudraflavone A (7), kuwanon G (8), albafurane C (9), mulberrofuran G (10), 3-O-acetyl-α-amyrin (11), 3-O-acetyl-β-amyrin (12) ursolic acid-3-O-acetate (13) and uvaol (14), were isolated from the barks of Morus nigra. Compounds 2, 8, 10, 12 and 14 are reported for the first time from this plant. The isolated compounds were elucidated by means of 1D and 2D NMR, UV, IR and MS, as well as by comparison with the literature data.

Taxodione, a DNA-binding compound from Taxodium distichum L. (Rich.).

8-beta-Hydroxypimar-15-en-19-oic acid (1), taxodione (2), 6,7-dehydro-8-hydrotaxodone (3), quercetin-3-O-beta-D-glucopyranoside (4), and shikimic acid (5) were isolated from the leaves of Taxodium distichum L. (Rich.) for the first time.