Publications by authors named "Ahmed Elkarim"
Article Synopsis
- CaMKII is suggested to play a significant role in the heart's protective responses to SGLT2 inhibitors, but the specifics of this relationship are not well understood.
- In a study with type 2 diabetic mice, empagliflozin reduced the likelihood of atrial fibrillation, while both empagliflozin and dapagliflozin helped prevent diabetic heart muscle damage.
- Experiments using a biosensor indicated that blocking CaMKII directly isn't necessary for SGLT2 inhibitors to exert their beneficial effects, implying the action may involve indirect effects on CaMKII or different pathways entirely.
Background: Anthranilic acid is an active compound with diverse biological activities such as anti-inflammatory, antineoplastic, anti-malarial and α-glucosidase inhibitory properties. It can also chelate transition metals to form complexes with applications as antipathogens, photoluminescent materials, corrosion inhibitors, and catalysts.
Results: Anthranilic acid complexes (1-10) of Zn(II), Bi(III), Ag(I), Fe(II), Co(II), Cu(II), Mn(II), Al, Ni(II), and Cr(III) were synthesized and characterized using thermogravimetric (TGA), elemental analysis, FT-IR, UV-vis spectrometry, mass spectrometry and magnetic susceptibility.