Human immunodeficiency virus type 1 (HIV-1) and human T-lymphotropic virus type I (HTLV-I) are two retroviruses which infect the same target, CD4+ T cells. This type of cell is considered the main component of the immune system. Since both viruses have the same means of transmission between individuals, HIV-1-infected patients are more exposed to the chance of co-infection with HTLV-I, and vice versa, compared to the general population.
View Article and Find Full Text PDFThe world has been suffering from the coronavirus disease 2019 (COVID-19) since late 2019. COVID-19 is caused by a virus called the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The human immunodeficiency virus (HIV) coinfection with SARS-CoV-2 has been reported in many patients around the world.
View Article and Find Full Text PDFThis paper studies the global stability of viral infection models with CTL immune impairment. We incorporate both productively and latently infected cells. The models integrate two routes of transmission, cell-to-cell and virus-to-cell.
View Article and Find Full Text PDFIn this paper, we study the stability analysis of latent Chikungunya virus (CHIKV) dynamics models. The incidence rate between the CHIKV and the uninfected monocytes is modelled by a general nonlinear function which satisfies a set of conditions. The model is incorporated by intracellular discrete or distributed time delays.
View Article and Find Full Text PDFIn this paper, a new synchronization problem for the collective dynamics among genetic oscillators with unbounded time-varying delay is investigated. The dynamical system under consideration consists of an array of linearly coupled identical genetic oscillators with each oscillators having unbounded time-delays. A new concept called power-rate synchronization, which is different from both the asymptotical synchronization and the exponential synchronization, is put forward to facilitate handling the unbounded time-varying delays.
View Article and Find Full Text PDFThis paper deals with the finite-time boundedness and stabilization problem for a class of switched neural networks with time-varying delay and parametric uncertainties. Based on Lyapunov-like function method and average dwell time technique, some sufficient conditions are derived to guarantee the finite-time boundedness of considered uncertain switched neural networks. Furthermore, the state feedback controller is designed to solve the finite-time stabilization problem.
View Article and Find Full Text PDFThe paper is devoted to the investigation of synchronization for an array of linearly and diffusively coupled inertial delayed neural networks (DNNs). By placing feedback control on a small fraction of network nodes, the entire coupled DNNs can be synchronized to a common objective trajectory asymptotically. Two different analysis methods, including matrix measure strategy and Lyapunov-Krasovskii function approach, are employed to provide sufficient criteria for the synchronization control problem.
View Article and Find Full Text PDFThis paper proposes a critical analysis of the existing literature on mathematical tools developed toward systems biology approaches and, out of this overview, develops a new approach whose main features can be briefly summarized as follows: derivation of mathematical structures suitable to capture the complexity of biological, hence living, systems, modeling, by appropriate mathematical tools, Darwinian type dynamics, namely mutations followed by selection and evolution. Moreover, multiscale methods to move from genes to cells, and from cells to tissue are analyzed in view of a new systems biology approach.
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