Publications by authors named "Ahmed Alyami"

Article Synopsis
  • The study investigates how variants in the HLA-G gene and soluble HLA-G (sHLA-G) levels may relate to susceptibility to COVID-19 in 65 patients compared to 67 healthy controls.
  • Key findings indicate that the 14-bp INS/DEL polymorphism increases the likelihood of experiencing COVID-19 symptoms, while the +3196C/G polymorphism appears protective.
  • Additionally, higher serum levels of sHLA-G were found in COVID-19 patients, suggesting that these genetic factors could inform on immune responses and help identify individuals at higher risk or needing targeted treatments.
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Article Synopsis
  • Research on antimicrobial resistance in Group B Streptococcus (GBS) isolates from Saudi Arabia is limited; this study analyzes 204 clinical isolates for genetic resistance to antibiotics.
  • Findings revealed high resistance rates to tetracycline (76.47%) and moderate resistance to erythromycin (36.76%) and clindamycin (25.49%); specific resistance genes were identified for different antibiotic classes.
  • The research highlights a concerning spread of antibiotic resistance across serotypes, emphasizing the need for ongoing surveillance and careful antibiotic prescribing in healthcare settings.
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Introduction: Detailed assessment of the population structure of group B (GBS) among adults is still lacking in Saudi Arabia. Here we characterized a representative collection of isolates from colonized and infected adults.

Methods: GBS isolates (n=89) were sequenced by Illumina and screened for virulence and antimicrobial resistance determinants.

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Background: () is known to cause various infections, most commonly urinary tract infections, and is a threat to hospitalized patients, especially in long-stay departments that utilize invasive devices. This study aims to fill the knowledge gap regarding epidemiology and antimicrobial resistance in Saudi Arabia. It investigates epidemiological patterns, resistance characteristics, and clinical outcomes among patients at King Fahad Medical City in Riyadh from 2019 to 2021.

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Human leukocyte antigen-G (HLA-G) is classified as non-classical HLA, located in the short arm of chromosome 6 and composed of seven introns and eight exons. The HLA-G gene has a lower frequency polymorphism in the coding area and higher variability at the regulatory 5'- and 3'-untranslated regions linked to HLA-G microRNA regulation. HLA-G molecule is known to have an immunomodulatory and tolerogenic features role.

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Objectives: Group B Streptococcus (GBS) has emerged as an important cause of severe infections in adults. However, limited data are available regarding the epidemiology of GBS in Saudi Arabia.

Methods: Isolates were collected over a period of eight months from colonized (n = 104) and infected adults (n = 95).

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Article Synopsis
  • A study conducted at King Fahad Medical City in Riyadh, Saudi Arabia, analyzed 3,579 cases of multi-drug resistant (MDR) infections from 2019 to 2021, revealing key epidemiological and microbiological insights.
  • The findings indicated that MDR infections were more common in males and children, with respiratory samples being the primary source, while resistance to certain antibiotics like aztreonam and imipenem was noted.
  • The study highlighted a significant correlation between septic shock, liver disease, and mortality in ICU patients, underlining the urgent need for improved infection control and management strategies in the region.
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Objectives: is an opportunistic organism that causes serious infections, particularly in immuno-compromised and hospitalized patients, along with the emergence of resistance traits. The COVID-19 pandemic has impacted the epidemiological pattern and resistance traits of infections as well as those of other bacteria. The study aims to assess the epidemiological patterns, resistance characteristics and clinical outcomes of in Saudi Arabia and the impact of the COVID-19 pandemic.

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Article Synopsis
  • The study focuses on an emerging pathogen that poses a public health risk and shows resistance to antimicrobial treatment, particularly affecting critically ill patients in the ICU.
  • The research analyzed clinical data and samples from 393 isolates, revealing that adult patients experienced more severe infections and higher mortality rates compared to pediatric patients, with septic shock being a key predictor of death.
  • The findings emphasize the need for ongoing surveillance efforts to address this pathogen as an increasing threat in healthcare settings.
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Background: Nursing staff are in direct contact with the consequences of the current c disease 2019 (COVID-19) crisis.

Design And Methods: Descriptive questionnaire-based cross-sectional survey of a sample of nursing staff working across Saudi Arabia.

Results: The study included ( = 431) nursing professionals.

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Allelochemicals are secondary metabolites which are not edible and can be used as growth regulators and bio-herbicides. The goal of current study was to assess allelopathic ability of (Sage-plant) flowers against weeds viz. (Wild oat), (Sun-spurge), (Goosefoot), (Canary-grass), and (Knotweed).

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