Publications by authors named "Ahmed Alsagheir"
Objective: To present the interim findings from a national study investigating the safety and efficacy of convalescent plasma (CP) containing detectable IgG antibodies as a treatment strategy for severe coronavirus disease 2019 (COVID-19).
Trial Design And Participants: An open label, two-arm, phase-II clinical trial conducted across 22 hospitals from Saudi Arabia. The intervention group included 40 adults (aged ≥18 years) with confirmed severe COVID-19 and the control group included 124 patients matched using propensity score for age, gender, intubation status, and history of diabetes and/or hypertension.
Background: The COVID-19 pandemic is expected to cause significant morbidity and mortality. The development of an effective vaccine will take several months to become available, and its affordability is unpredictable. Transfusion of convalescent plasma (CP) may provide passive immunity.
View Article and Find Full Text PDFArticle Synopsis
- Mammalian target of rapamycin inhibitors (mTORi), like sirolimus and everolimus, are medications used for treating certain cancers and in organ transplant procedures.
- Interstitial lung disease (ILD) is a potential complication associated with mTORi, with more cases linked to sirolimus compared to everolimus, possibly due to sirolimus being more widely used earlier on.
- A specific case is presented where a kidney transplant patient developed ILD from sirolimus but showed quick improvement after switching to everolimus.
Objective/background: The Eastern Mediterranean Blood and Marrow Transplantation (EMBMT) group has accumulated over 31 years of data and experience in hematopoietic stem cell transplantation (HSCT), particularly in hemoglobinopathies, severe aplastic anemia, inherited metabolic and immune disorders, in addition to a wide array of hematologic malignancies unique to this region. A regional update in current HSCT trends is highly warranted. We studied the trends of HSCT activities in World Health Organization-Eastern Mediterranean (EMRO) region, surveyed by the EMBMT, between 2011 and 2012.
View Article and Find Full Text PDFObjective: To measure the effect of providing a detailed description of coronary angiography risks on obtaining informed consent from Saudi Arabian patients.
Methods: This randomized controlled trial was conducted at King Khalid University Hospital, Riyadh, Saudi Arabia from August 2006 to June 2007. Patients were randomized to either an information sheet containing brief information on procedure-related risks (brief sheet), or full disclosure of risks (detailed sheet).