Tocilizumab use for optic nerve compression in thyroid eye disease: a prospective longitudinal cohort.

Purpose: To assess the effectiveness of tocilizumab in reverting the signs and symptoms of dysthyroid optic neuropathy (DON) in thyroid eye disease and the need for emergency orbital decompression. The secondary outcomes are to identify the optimal number of tocilizumab cycles to achieve the primary outcome, to analyze the association between thyroid stimulating immunoglobulin (TSI), clinical activity score (CAS) and proptosis in response to the treatment and the need for rehabilitative orbital decompression.

Methods: Prospective longitudinal cohort study that included 13 patients who had unilateral or bilateral dysthyroid optic neuropathy (DON) due to severe and progressive sight-threatening thyroid eye disease based on the CAS system.

A sequential approach to the management of an advanced case of pellucid marginal degeneration.

Purpose: We report a sequential approach in the management of a case with advanced pellucid marginal degeneration (PMD). The management was tailored based on the patient's corneal topography and degree of corneal astigmatism. Full thickness corneal transplants in cases of PMD carry a prolonged rehabilitation period and the risk of graft failure.

A 46-Year-Old Woman with a 4-Year History of Graves Disease, with Severe Corticosteroid-Unresponsive Thyroid Eye Disease, Successfully Treated with Tocilizumab.

BACKGROUND Tocilizumab is a therapeutic biologic antagonist of the interleukin-6 (IL-6) receptor that has been approved to treat some autoimmune and chronic inflammatory diseases. This report is of a patient with a history of Graves disease and severe corticosteroid-unresponsive thyroid eye disease that included edema of the optic nerve and choroid, which was successfully treated with tocilizumab. CASE REPORT A 46-year-old woman with a 4-year history of Graves disease presented with acutely progressive bilateral severe optic nerve compression, severe bilateral optic nerve edema, bilateral restriction of eye movement, and bilateral choroidal folds.

Improvement of the aerodynamic behavior of a sport utility vehicle numerically by using some modifications and aerodynamic devices.

The present study proposes aerodynamically optimized exterior designs of a sport utility vehicle using computational fluid dynamics analysis based on steady-state Reynolds-averaged Navier-Stokes turbulence models. To achieve an optimal design, modifications of the outer shape and adding some aerodynamic devices are investigated. This study focuses on modifying this vehicle model's upper and front parts.

Improvement of the aerodynamic behaviour of the passenger car by using a combine of ditch and base bleed.

The current study investigates different methods to minimize the drag coefficient (C) without ignoring the safety factor related to the stability of a vehicle, i.e., the lift coefficient (C).

Management of limbal stem cell deficiency by amnion-assisted conjunctival epithelial redirection using vacuum-dried amniotic membrane and fibrin glue.

Purpose: To study the outcome of a modified amnion-assisted conjunctival epithelial redirection (ACER) technique using vacuum-dried amnion (Omnigen) and fibrin glue for managing total limbal stem cell deficiency (LSCD).

Method: A retrospective, interventional case series of all patients with total LSCD who underwent limbal stem cell transplant (LSCT) using the modified ACER procedure between 2016 and 2019. The outcome was defined as: (1) success: complete corneal re-epithelialisation without conjunctivalisation; (2) partial success: sub-total corneal re-epithelialisation with partial non-progressive conjunctivalisation sparing the visual axis and (3) failure: conjunctivalisation affecting the visual axis.

Antimicrobial peptides in human corneal tissue of patients with fungal keratitis.

Background: Fungal keratitis (FK) is the leading cause of unilateral blindness in the developing world. Antimicrobial peptides (AMPs) have been shown to play an important role on human ocular surface (OS) during bacterial, viral and protozoan infections. In this study, our aim was to profile a spectrum of AMPs in corneal tissue from patients with FK during the active pase of infection and after healing.

Mechanism of fluid leak in non-traumatic corneal perforations: an anterior segment optical coherence tomography study.

Aim: Non-traumatic corneal perforations (CPerfs) may present with shallow/flat or formed anterior chamber (AC). This study uses anterior segment optical coherence tomography (ASOCT) to ascertain these differences.

Method: The study included 14 eyes of 13 patients.

Association between unilateral quiescent stromal herpetic keratitis and bilateral dry eyes.

Purpose: According to our clinical observation, patients with quiescent herpes simplex virus (HSV) stromal keratitis often seem to present with signs of dry eye in the contralateral eye. Our goal was to compare dry eye signs and symptoms in both eyes of patients with quiescent HSV stromal keratitis with those of age- and sex-matched control subjects with healthy corneas.

Methods: A case-control study with 24 subjects per group.