Sheep as a Model for Liver Transplantation.

Objective: Experimental animal liver transplantation is the initial step, before the application of the procedure on humans. Canine and swine transplantation were used to perfect the technical aspects of the procedure. Small animals such as rats were mainly utilized to study the metabolic and immunological aspects of liver transplantation.

The use of ex-vivo liver perfusion circuit in sheep model: Preliminary report.

Objectives: To describe a novel animal model for ex-vivo liver perfusion.

Methods: This study was carried out at King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia, between September 2016 and January 2019. We assembled a perfusion circuit operated by a continuous pressure-driven arterial pump with continuous portal and arterial pressure and volume measurements.