Impact of Resolvin-E1 and Maresin-1 on Bone Marrow Stem Cell Osteogenesis under Inflammatory Stress.

Periodontal disease is characterized by inflammation and bone loss. Central to its pathogenesis is the dysregulated inflammatory response, complicating regenerative therapies. Mesenchymal stem cells (MSCs) hold significant promise in tissue repair and regeneration.

Anti-Inflammatory Effect of Specialized Proresolving Lipid Mediators on Mesenchymal Stem Cells: An In Vitro Study.

An interconnection between tissue inflammation and regeneration has been established through the regulation of defense and repair mechanisms within diseased dental tissue triggered by the release of immune-resolvent mediators. To better our understanding of the role of specific pro-resolving mediators (SPMs) in inflamed human bone marrow-derived mesenchymal stem cells (hBMMSCs), we studied the effects of Resolvin E1 (RvE1) and Maresin 1 (MaR1) in lipopoly-saccharide (LPS) stimulated hBMMSCs. The hBMMSCs were divided into five different groups, each of which was treated with or without SPMs.

Viability of Quercetin-Induced Dental Pulp Stem Cells in Forming Living Cellular Constructs for Soft Tissue Augmentation.

Autogenous gingival grafts used for root coverage or gingival augmentation procedures often result in donor site morbidity. Living cellular constructs as an exogenous alternative have been proven to be associated with lower morbidity. With the available background information, the present study aims to assess if quercetin-induced living cell constructs, derived from dental pulp stem cells, have the potential to be applied as a tool for soft tissue augmentation.

Modulation of the Dental Pulp Stem Cell Secretory Profile by Hypoxia Induction Using Cobalt Chloride.

The action of stem cells is mediated by their paracrine secretions which comprise the secretory profile. Various approaches can be used to modify the secretory profile of stem cells. Creating a hypoxic environment is one method.

Face Validity and Psychometric Evaluation of the Available Oral Health-related Quality of Life Instruments: A Systematic Review.

Purpose: A growing recognition of the importance of oral health-related quality of life (OHRQoL) has led to the development of several instruments to measure their relationship with health. The objective of this review was to update the knowledge on the general and psychometric characteristics of the instruments to measure the quality of life (QoL) related to oral health that emerged after publication in 1997 of the results of the conference 'Measuring Oral Health and QoL'.

Materials And Methods: A bibliographic search was carried out to identify publications published in January from 1998 to June 2018, using EMBASE, PubMed, Scopus, CINAHL and Web of Science databases.

Controlled release of diclofenac sodium through acrylamide grafted hydroxyethyl cellulose and sodium alginate.

To reinforce the hydroxyethyl cellulose for using it in biomedical and pharmaceutical applications as a drug delivery systems, the grafting of acrylamide onto hydroxyethyl cellulose (AAm-g-HEC) was achieved by Ce(IV) induced free radical polymerization. The AAm-g-HEC was then blended with sodium alginate (NaAlg) to prepare pH-sensitive interpenetrating network (IPN) microspheres (MPs) by emulsion-crosslinking method using glutaraldehyde (GA) as a crosslinking agent. The produced MPs are almost spherical in nature with smooth surfaces.

Effect of long acting local anesthetic on postoperative pain in teeth with irreversible pulpitis: Randomized clinical trial.

Objective: The objective of this study was to compare the effect of long acting anesthetics on postoperative pain in teeth with irreversible pulpitis.

Methodology: Forty patients were randomly assigned into two groups of twenty patients each. Each patient who fit the inclusion criteria was administered local anesthesia before undergoing root canal treatment.

Semi-interpenetrating network of acrylamide-grafted-sodium alginate microspheres for controlled release of diclofenac sodium, preparation and characterization.

The semi-interpenetrating networks (semi-IPNs) of acrylamide grafted sodium alginate (AAm-g-NaAlg) microspheres (MPs) were prepared by emulsion-crosslinking method using glutaraldehyde (GA) as a crosslinking agent. The grafting of acrylamide onto sodium alginate was prepared by free-radical graft polymerization using ceric ammonium nitrate (CAN) as initiator at three acrylamide concentrations with monomer to polymer ratio of 1:1, 2:1 and 3:1, respectively. The grafting efficiency was found to be 91%.

Carrier-based root canal filling materials: a literature review.

A review of the literature on the use of carrier based obturation materials focusing on Thermafil and Resilon based obturator (RealSeal 1) are presented in this article. The review addressed the history, apical leakage, coronal leakage, biocompatibility, sealing ability and clinical success of Thermafil and RealSeal 1. Based on the studies gathered, this review concluded that both treatment techniques (Thermafil and RealSeal 1) did not provide excellent apical sealing ability.

Avulsed immature permanent central incisors obturated with mineral trioxide aggregate: a case report.

The endodontic management of immature permanent incisors in young children can be challenging. This case reported an avulsed immature maxillary central incisors that underwent complete endodontic obturation using mineral trioxide aggregate. A 10-year-old male who suffered a fall injury avulsed both his central incisors.

The effect of root canal sealers and timing of cementation on the microlekage of the parapost luted with resin cement.

Objectives: The objectives of the study were to study the effect of root canal sealers either eugenol or non-eugenol and timing of cementation on microleakage of the parapost luted with resin cement.

Materials And Methods: Seventy extracted human, single-rooted teeth were instrumented using a crown-down technique. All teeth were instrumented up to a size 50 .

Fracture resistance of teeth obturated with RealSeal using two different chelating agents: an in vitro study.

Objectives: The aim of this study was to evaluate the fracture resistance of endodontically treated teeth filled with a resin-based obturation material using two different chelating agents.

Methods And Materials: Forty extracted single-canal human teeth were prepared, instrumented, and randomly divided into three groups: Group 1 (n=15) received a final flush with 10 ml of neutralized 17% EDTA, followed by 10 ml of sodium hypochlorite (NaOCl), then obturated using lateral condensation with RealSeal. Group 2 (n=15) received a final flush of BioPure MTAD, followed by 10 ml of NaOCl, then obturated using lateral condensation with RealSeal.

Controlled release of theophylline through semi-interpenetrating network microspheres of chitosan-(dextran-g-acrylamide).

Semi-interpenetrating network microspheres of chitosan-(dextran-g-acrylamide) were prepared by emulsion-crosslinking method using glutaraldehyde (GA) as a crosslinking agent. Graft copolymerization of dextran with acrylamide (Dx-g-AAm) was carried out by aqueous free-radical polymerization using ceric ammonium nitrate (CAN) as initiator. The grafting efficiency was found to be 92%.

In-vitro evaluation of microleakage of an orthograde apical plug of mineral trioxide aggregate in permanent teeth with simulated immature apices.

This in vitro study evaluated the seal created by varying depths of mineral trioxide aggregate (MTA) plugs placed in an orthograde fashion in five groups of 10 teeth. One group received a 2 mm thick orthograde apical plug of MTA, the second group a 5 mm apical MTA plug, and the third group a 2 mm apical MTA plug with a second 2 mm increment, 24 h later. The remaining portion of the canal in these groups was left unfilled.