Telomerase activator-65 and pomegranate peel improved the health status of the liver in aged rats; multi-targets involved.

Objectives: This study was undertaken to investigate the efficacy of telomerase activator-65 (Ta-65) and pomegranate peel against aging-induced deteriorations in the liver.

Materials And Methods: The rats were divided into four groups: control, aged, aged rats treated with Ta-65, and pomegranate orally for two months.

Results: Aging significantly increased the serum levels of total protein, globulins, and protein carbonyl and reduced the insulin-like growth factor 1 (IGF-1).

leaves methanolic extract alleviates diethylnitrosamine-induced hepatocellular carcinoma in rats.

This study evaluated the antitumor activity of a methanolic extract from the leaves of (ZSCL) against diethylnitrosamine (DENA)-induced hepatocarcinoma in rats. The phytochemical constituents, in vitro antioxidant and cytotoxic activities of ZSCL extract were investigated. Male Wistar rats were distributed among 6 groups: () normal control; () ZSCL1-treated rats (100 mg/kg body mass; "b.