Publications by authors named "Ahmed Abd-Alkhalek"
Rhoifolin, baicalein 5,6-dimethyl ether and agathisflavone prevent amnesia induced in scopolamine zebrafish (Danio rerio) model by increasing the mRNA expression of bdnf, npy, egr-1, nfr2α, and creb1 genes.
Eur J Pharmacol
December 2024
Article Synopsis
- Growing interest in cognitive dysfunction related to Alzheimer's disease (AD) highlights the need for effective therapies, as current treatments have limitations.
- Flavonoids have shown promise due to their antioxidative, anti-inflammatory, and anti-amyloidogenic properties, which could help combat AD symptoms.
- In this study, researchers tested three flavonoids in zebrafish to assess their potential to improve memory, reduce anxiety, and lower oxidative stress, finding that these compounds positively influence gene expression related to neuroprotection and synaptic function.
Petitgrain essential oil (PGEO) is derived from the water distillation process on mandarin () leaves. The chemical constituents of PGEO were analyzed by gas chromatography/mass spectrometry (GC/MS) method which revealed the presence of six compounds (100%). The major peaks were for methyl-N-methyl anthranilate (89.
View Article and Find Full Text PDFGC/MS analysis and potential synergistic effect of mandarin and marjoram oils on .
J Enzyme Inhib Med Chem
December 2022
can cause chronic gastritis, peptic ulcer, and gastric carcinoma. This study compares chemical composition and activity of mandarin leaves and marjoram herb essential oils, and their combined oil. GC/MS analysis of mandarin oil revealed six compounds (100% identified), mainly methyl--methyl anthranilate (89.
View Article and Find Full Text PDFRhoifolin (Rho) exerts many biological activities such as anticancer, antidiabetic, hepatoprotective, antirheumatic, antibacterial, and antiviral properties. The neuroprotective action of this compound has not been studied. The goal of this study was to investigate the improvement impact of Rho on scopolamine (Sco)-induced zebrafish anxiety, amnesia, and brain oxidative stress and to elucidate the underlying mechanisms involved.
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