Natural benzofuran derivatives as promising scaffold for alleviating Alzheimer symptoms: acetylcholinesterase inhibition, structure activity relationship and studies.

Three isolated natural benzofuran compounds and four semi-synthesized benzofuran derivatives and were evaluated for their acetylcholinesterase inhibition assay. Most of the tested compounds showed moderate activity with IC ranged from 102.4 ± 5.

Non-ulcerogenic pyrazolyl 2-hydroxychalcones and pyrazolylpyrazolines derived from naturally existing furochromone (khellin): semi-synthesis, docking study and anti-inflammatory activity.

Novel pyrazolyl 2-hydroxychalcone derivatives and pyrazolylpyrazoline derivatives and derived from the naturally existing furochromone (Khellin) were synthesized and evaluated for their anti-inflammatory activity. Most of the synthesized compounds showed better or comparable activity to that of Diclofenac as reference drug. Twelve compounds were evaluated for their ulcerogenic potential and exhibited no ulcerogenic effect.