Optimization of oil yield of Pelargonium graveolens L'Hér using Box-Behnken design in relation to its antimicrobial activity and in silico study.

Pelargonium graveolens L'Hér is an important species of genus Pelargonium with an economic value. The unique rose scent of its oil is used in perfume and cosmetic industry. The oil is characterized by the presence of citronellol, geraniol and rose oxide.

Formulation and evaluation of alginate-gelatin hydrogel scaffolds loaded with zinc-doped hydroxyapatite and 5-fluorouracil.

Alginate and gelatin are natural macromolecules used to formulate biocompatible drug delivery systems. Hydroxyapatite (HA) is an osteophilic ceramic used to prepare bone scaffolds. The current study aimed at preparing and characterizing HA, zinc-doped HA, and 5-fluorouracil(5-FU)-loaded alginate-gelatin-based hydrogel scaffolds using different crosslinking solutions.

Optimization of Meloxicam Solid Dispersion Formulations for Dissolution Enhancement and Storage Stability Using 3 Full Factorial Design Based on Response Surface Methodology.

This study aimed to formulate and optimize solid-dispersion of meloxicam (MX) employing response-surface-methodology (RSM). RSM allowed identification of the main effects and interactions between studied factors on MX dissolution and acceleration of the optimization process. 3 full factorial design with 27 different formulations was proposed.

A comparative study, distribution, predicted no-effect concentration (PNEC) and contamination assessment of phenol with heavy metal contents in two coastal areas on the Egyptian Mediterranean Sea coast.

This study comparing the expected pollution status of phenol along with heavy metals in sediments of two economic regions on the Mediterranean Sea coast using equilibrium partitioning method (EPM) as well as exposure of fishermen and populations to these sediments through ingestion and skin contact while swimming. El-Dekhila (ED) and Abu Talat (AT) regions were different in sediment texture and pollution sources. The expected ecological hazards of phenol in the studied areas were carried out using the equilibrium partitioning method (EPM) by which the partition coefficient of organic carbon-water, K (logK> 0.

Application of Box-Behnken design for optimization of phenolics extraction from Leontodon hispidulus in relation to its antioxidant, anti-inflammatory and cytotoxic activities.

To the best of our knowledge, there have been no phytochemical studies concerning the wild plant Leontodon hispidulus Boiss. (Asteraceae). Optimization of the green extraction process of the plant aerial parts, identification of main phenolic compounds, evaluation of antioxidant, anti-inflammatory and anticancer activities of the optimized extract have been carried out.

Accumulation of heavy metals by Avicennia marina in the highly saline Red Sea coast.

Phytoremediation of eight metals in mangrove forests was investigated by focusing on Avicennia marina at three locations along the Egyptian Red Sea coast. Average concentrations of metals in sediment followed the sequence Fe > Mn > Zn > Pb > Cr > Cu > Ni, while Cd was below the detection limit. Metal pollution index and enrichment factor indicated contamination of sediment by Pb, Cu, and Mn.

Formulation, Pharmacokinetics evaluation, and IVIVC Assessment of Gliclazide Multiparticulates in Rat Model.

In vitro and in vivo studies of gliclazide (GLZ)-loaded freeze-dried alginate-gelatin (AL-GL) beads were carried out, aiming to modify its oral bioavailability. Crosslinked freeze-dried GLZ AL-GL beads (particle size: 1.5- and 3.

Optimization of gliclazide loaded alginate-gelatin beads employing central composite design.

The aim of this study was to optimize the formulation of alginate-gelatin (AL-GL) beads containing gliclazide (GLZ) employing design of experiments (DOE). DOE enabled identification of the interaction between the studied factors, deep understanding of GLZ release pattern and acceleration of the optimization process. A three-factor, three-level face centered design was employed.

Seasonal variation of nutrient salts and heavy metals in mangrove (Avicennia marina) environment, Red Sea, Egypt.

In the Egyptian Red Sea coast, nutrient salts, major ions, and heavy metals ion concentrations were examined in mangroves and the results were compared to respective concentrations in a reference area. Water samples were collected during the four seasons of 2012 from three different mangrove regions, Safaga, Abo Gheson, and El Quseer, besides, a mangrove free region, Marsa Alam. A temporal variation in the chemical composition of seawater of the mangrove and reference regions was recorded.

Stability and bioavailability of diltiazem/polyethylene oxide matrix tablets.

The aim of this study was to prepare and evaluate in vitro and in vivo; Diltiazem-Hydrochloride (DTZ) in sustained-release matrix tablets. Stability of DTZ tablets prepared with polyethylene oxide (MWs 900 000, 4 000 000, and 8 000 000) with or without addition of electrolytes was carried-out for 1-month, under short-term storage at 40 °C/75% RH. Stability was evaluated by DTZ content, DSC and drug release using the Flow-Through Cell (USP # IV).

Controlled porosity osmotic pump system for the delivery of diclofenac sodium: in-vitro and in-vivo evaluation.

The objective of this study was to develop controlled porosity osmotic pump (CPOP) tablets of diclofenac sodium (DS). The influence of different cores (polymers and osmogens) and coats (thickness and porosigen content) on DS release were studied. Results revealed that decreasing HPMC viscosity grade from 4000cp (K4M) to 15cp (E15) increased DS release.