Publications by authors named "Ahmed A Bayoumy"

Background: Surgical removal of thromboembolic material by pulmonary endarterectomy (PEA) leads within months to the improvement of right ventricular (RV) function in the majority of patients with chronic thromboembolic pulmonary hypertension. However, RV mass does not always normalize. It is unknown whether incomplete reversal of RV remodeling results from extracellular matrix expansion (diffuse interstitial fibrosis) or cellular hypertrophy, and whether residual RV remodeling relates to altered diastolic function.

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Article Synopsis
  • Right ventricular (RV) wall tension in pulmonary arterial hypertension (PAH) is influenced by both pressure and volume, where larger volumes lead to increased wall tension.
  • In treatment-naïve PAH patients, 54% experience early reflected wave returns during mid-systole, correlating with more significant RV hypertrophy compared to those with later wave returns.
  • After treatment, improvements in arterial stiffness and a delay in the reflected wave timing were observed, indicating that treatment not only reduces pulmonary vascular resistance (PVR) but also affects the hemodynamics of RV function.
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Background: The major complication of COVID-19 is hypoxaemic respiratory failure from capillary leak and alveolar oedema. Experimental and early clinical data suggest that the tyrosine-kinase inhibitor imatinib reverses pulmonary capillary leak.

Methods: This randomised, double-blind, placebo-controlled, clinical trial was done at 13 academic and non-academic teaching hospitals in the Netherlands.

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Background: Pulmonary arterial hypertension (PAH) is a serious disease with increased morbidity and mortality. The need for an individualized patient treatment approach necessitates the use of risk assessment in PAH patients. That may include a range of hemodynamic, clinical, imaging and biochemical parameters derived from clinical studies and registry data.

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Pulmonary vascular resistance (PVR) and compliance are comparable in proximal and distal chronic thromboembolic pulmonary hypertension (CTEPH). However, proximal CTEPH is associated with inferior right ventricular (RV) adaptation. Early wave reflection in proximal CTEPH may be responsible for altered RV function.

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