Publications by authors named "Ahmed A A Mohamed"
Purpose: To assess the pathological macular changes with optical coherence tomography (OCT) before the removal of silicone oil (SiO) in eyes that had undergone pars plana vitrectomy for complicated forms of retinal detachment (RD).
Patients And Methods: Subjects included 48 patients (51 eyes) with complicated RD including proliferative vitreoretinopathy, proliferative diabetic retinopathy, recurrent RD, penetrating trauma, uveitis, giant retinal tears, and macular holes. All the eyes had undergone SiO injection.
Background: The purpose of this study was to assess the outcome of pars plana vitrectomy using a 20-gauge transconjunctival cannulated sutureless system with air or silicone oil tamponade in cases of retinal detachment of different etiologies.
Methods: A prospective study was performed in 60 eyes from consecutive 60 patients who underwent 20-gauge transconjunctival cannulated sutureless vitrectomy (30 eyes with air tamponade and 30 eyes with silicone oil tamponade), with the inclusion of a further 30 patients who underwent conventional 20-gauge vitrectomy and served as a control group. The main outcome measures were intraocular pressure, wound leakage, and comfort score.
Purpose: To assess the occurrence and magnitude of corneal topographic changes in phakic eyes undergoing Transconjuctival Cannulated 20 gauge Vitrectomy (TC20V) without scleral buckling or silicone oil tamponade.
Setting: Prospective randomized controlled study done at Egyptian Eye Academy.
Methods: Forty eyes of 40 patients underwent TC20V for a variety of vitreo-retinal conditions over a 1 year follow-up period.
Article Synopsis
- TNF activates two main receptors (TNFR1 and TNFR2) to trigger various signaling pathways, including NF-kappaB and JNK, but their activation mechanisms differ.
- TNFR1 primarily activates NF-kappaB, while JNK can be activated by either receptor.
- Caspases, particularly caspase-3, influence JNK activation but do not affect NF-kappaB activity, indicating that TNF receptor signaling events have distinct pathways and regulatory mechanisms.
The activation of the extracellular signal-regulated kinases (ERKs) by tumour necrosis factor-alpha (TNF) receptors (TNFRs) is an integral part of the cytokine's pleiotropic cellular responses. Here we report differences in the caspase sensitivity and TNFR subtype activation of members of the ERK family. Inhibition in HeLa cells of caspase function by pharmacological inhibitors or the expression of CrmA (cytokine response modifier A), a viral modifier protein, blocks TNF-induced apoptosis or caspase-dependent protein kinase Cdelta and poly(ADP-ribose) polymerase protein degradation.
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