Impact of Dual Antiplatelet Therapy Versus Monotherapy in Acute Stroke Management: A Systematic Review.

This systematic review evaluates the comparative efficacy and safety of dual antiplatelet therapy (DAPT) versus monotherapy in the management of acute ischemic stroke and transient ischemic attack (TIA). Six studies, published between 2019 and 2024, were included, focusing on patient outcomes such as stroke recurrence, functional recovery, and safety measures. The findings consistently demonstrated that DAPT, particularly combinations like aspirin with clopidogrel or cilostazol, significantly reduced stroke recurrence and improved functional outcomes as compared to monotherapy, without a notable increase in major bleeding risk.