Identification of Circulating Tumor Cells Using Plasmonic Resonance Effect: Lab-on-a-Chip Analysis and Modelling.

Circulating tumor cells are widely used as biomarkers of cancer. Although early detection of these cells is vital for diagnosis and prognosis of deadly cancer, it is still a challenging issue due to the complex matrix of blood and their low presence in the bloodstream. In the present study, we propose a micro-channeled lab-on-a-chip system using two distinct methods based upon dielectrophoretic force and electrical properties of cells to increase the cell detection capability and identification efficiency and accuracy.

Separation by nanoparticles plasmonic resonance with low stress in microfluidics channel (analytical and design).

In this study, nanoparticles near-field plasmonic resonance is used to improve the traditional cell separation main outputs such as viability and efficiency. The live cells viability is severely depend on stresses, which are applied on cells in the microfluidics channel. Hence, for improving the cell viability, the enforced stresses inside of the structure should be declined.

Design and simulation of perturbed onion-like quantum-dot-quantum-well (CdSe/ZnS/CdSe/ZnS) and its influence on fluorescence resonance energy transfer mechanism.

In this study, the authors investigate one of the biological sensory applications (fluorescence resonance energy transfer (FRET)) that has astonishing influence on implementation of the bio-medical assays. For the first time, in this study, the new inorganic modified nanoparticle structure (quantum-dot quantum-well (QDQW) heteronanocrystal) is used as donor particle. By considering the mentioned structure, the authors can easily manipulate the donor emission spectrum and all parameters of FRET, such as overlapping between the donor emission and acceptor absorption.

Design and simulation of nano-bio sensors for dye molecules targeting to enhance targeting efficiency (smart targeting).

In this article, the targeting of dye molecules as an important goal is probed and simulated by quantum dots and through the particle swarm optimization algorithm and fluorescence resonance energy transfer mechanism. At first, we design a nano-bio sensor, based on the fluorescence resonance energy transfer mechanism, which operates in a wide range of wavelength and is very sensitive to fluorescence resonance energy transfer parameters such as overlapping between donor and acceptor, Föster radius, and energy transfer rate from donor to acceptor. In fact, the alteration of nano-bio sensor parameters acts as the heart of our sensor.

Nanobio applications of quantum dots in cancer: imaging, sensing, and targeting.

In this article, the syntheses and optical properties of core/shell quantum dot (CdSe/ZnS) and their applications are reviewed. Nevertheless, the main focus is to provide an overview on biological applications of quantum dots that contain imaging, targeting, and sensing. We discuss the different synthetic methods, optical properties (photoluminescence intensity, absorption, and fluorescence spectra), and their dependence on shape, size, and inner structure of quantum dots.