Publications by authors named "Ahmad Safdar"
Rare case of wtTTR amyloidosis and MGUS in a patient with lung adenocarcinoma.
BMJ Case Rep
December 2024
Amyloidosis is a rare, multisystem disease that leads to deposition of misfolded proteins in various organs. This case report presents a patient with cancer with a rare diagnosis of diffuse alveolar-septal transthyretin (TTR) amyloidosis with subsequent protein electrophoresis identifying monoclonal gammopathy of unknown significance. It highlights the association of amyloidosis with malignancy and the importance of including workup for plasma cell dyscrasias in patients found to have TTR amyloidosis.
View Article and Find Full Text PDFManagement of iatrogenic ascending aortic dissection after percutaneous intervention of chronic total occlusion.
Catheter Cardiovasc Interv
December 2024
Article Synopsis
- This study examines the occurrence and management of iatrogenic ascending aortic dissection following percutaneous intervention for chronic total occlusion in patients.
- A review of patient data from 2020 to 2022 revealed six cases of aortic dissection, caused by various procedural issues, but all were managed conservatively without needing urgent surgery.
- The findings suggest that though aortic dissection is rare, it is more common in CTO PCI than in non-CTO PCI, and IVUS-guided interventions can be safely performed if patients remain stable.
Pharmacological management of transthyretin amyloid cardiomyopathy: a scoping review.
Eur Heart J Cardiovasc Pharmacother
October 2024
Article Synopsis
- * A total of 19 studies were analyzed, highlighting promising results with drugs like tafamadis and RNA interference treatments that improve quality of life for patients, especially when treatments start early.
- * Despite the potential of multiple therapies, significant gaps remain in long-term outcomes and their economic implications, indicating a need for further research and exploration in this field.
Introduction: Pomalidomide (Pom) has demonstrated synergistic antiproliferative activity in combination regimens as a result of its distinct anticancer, antiangiogenic, and immunomodulatory effects. This review aimed to compare outcome measures of different Pom regimens for relapsed/refractory multiple myeloma.
Methods: A comprehensive literature search identified a total of 1374 studies.