Assessment of anti-nociceptive effect of allopurinol in a neuropathic pain model.

Background: This study aimed to investigate the antinociceptive effect of allopurinol, a xanthine oxidase inhibitor, in the chronic constriction injury (CCI) to sciatic nerve rat model of neuropathic pain.

Methods: Allopurinol administration (30, 60, 90 mg/kg, i.p.