Synthesis of designed new 1,3,4-oxadiazole functionalized pyrano [2,3-f] chromene derivatives and their antimicrobial activities.

Diethyl 2-(((4-methyl-2-oxo-2H-chromen-7-yl)oxy)methylene)malonate was synthesized from coumarin 1 and diethyl ethoxymethylene malonate in ethanol, followed by cyclization in diphenyl ether to give chromene-9-carboxylate . Sugar hydrazones were formed by reacting hydrazide with D-galactose, D-mannose, and D-xylose, then acetylated to per--acetyl derivatives . Heating with acetic anhydride at 100 °C gave oxadiazolines .

Design, synthesis, and molecular docking of new phenothiazine incorporated -Mannich bases as promising antimicrobial agents.

The present work aims to synthesize four series of phenothiazine incorporation Mannich bases. Therefore, 10-methyl-10H-phenothiazine-3-sulfonamide which was subjected to react with some secondary amines and formaldehyde to give the Mannich bases , and -. Compound was then subjected to react with some secondary amines and formaldehyde to give the corresponding Mannich bases .

Synthesis of tetrazole hybridized with thiazole, thiophene or thiadiazole derivatives, molecular modelling and antimicrobial activity.

Background: Tetrazole-based derivatives and their electronic structures have displayed interesting antimicrobial activity.

Methods: The tetrazole-based hybrids linked with thiazole, thiophene and thiadiazole ring systems have been synthesized through various chemical reactions. The computational method DFT/B3LYP has been utilized to calculate their electronic properties.