Efficacy and safety of a novel pegylated interferon alpha-2a in Egyptian patients with genotype 4 chronic hepatitis C.

Background: Hepatitis C virus (HCV) genotype 4 is a common infection in Egypt and is the leading cause of liver disease.

Objective: To study the efficacy and safety of a novel 20 kD pegylated interferon alpha-2a derived from Hansenula polymorpha in combination with ribavirin for the treatment of Egyptian patients with genotype 4 chronic hepatitis C (CHC).

Methods: One hundred seven patients with genotype 4 CHC were involved in the present study.

Efficacy of percutaneous radiofrequency ablation in the management of hepatocellular carcinoma with schistosomisis.

Radiofrequency ablation (RFA) is a well known therapeutic modality in the curative treatment of hepatocellular carcinoma (HCC). The aim of this work was to assess the efficacy of percutaneous RFA in patients with tumors < or = 3.5 cm regarding the ability to achieve full tumor necrosis and local recurrence in patients with previous schistosomal infection.