Activation of FGFR genes by genetic and epigenetic alterations in uterine leiomyomas.

Background: Fibroblast growth factor 1-4 (FGFR1-4) are well-known oncogenic drivers in many cancer types. Here, we studied the role of FGFRs in uterine leiomyoma (UL) that is a benign neoplasm arising from the myometrium and the most common tumour in women. Although ULs can be classified to molecular subtypes based on genetic drivers, potential secondary drivers are not well characterised.

Rising oceans, climate change, food aid, and human rights in the Marshall Islands.

Climate change impacts are expected to produce more frequent, longer and unpredictable drought periods with further saltwater intrusion in the Marshall Islands. As a result, a significant return to traditional food cropping is unlikely. This will lead to an increased dependence on food aid, especially in the outer atoll populations.

Literacy promotion in primary care pediatrics: can we make a difference?

Background: Reading skills are critical to children's success in school and the increasingly technologic workforce. Children from low-income families are at risk for home environments that fail to promote emergent literacy and for reading failure. A home environment that encourages learning and parents who are involved in their children's education are important factors in school achievement.

Estimating Bacterioplankton Production by Measuring [H]thymidine Incorporation in a Eutrophic Swedish Lake.

Bacterioplankton abundance, [H]thymidine incorporation, CO(2) uptake in the dark, and fractionated primary production were measured on several occasions between June and August 1982 in eutrophic Lake Norrviken, Sweden. Bacterioplankton abundance and carbon biomass ranged from 0.5 x 10 to 2.

Effects of lysine-vasopressin treatment on renal function in burned pigs.

The effects of lysine vasopressin (LVP) on renal excretory function and renal blood flow were studied in anesthetized and burned pigs either treated conservatively or by early excision 5 hours after burn. Renal perfusion was measured with radioactive microspheres. Diuresis and the urinary excretion of sodium and potassium were determined.

Lysine-vasopressin in excisional treatment of burns in pigs. Decreased blood loss and earlier circulatory recovery.

The hemodynamics were monitored during 24 hours in piglets anesthetized with Pentothal-N2O/O2, submitted to 33% full-thickness skin burn and resuscitated with 2.4 ml/kg/% burn of 100 mmol NaCl in 2.5% glucose.

The effects of lysine-vasopressin on hemodynamics during early post burn period in pigs.

In order to investigate the central and peripheral circulatory effects of a vasoactive drug, lysin vasopressin (LVP), in the early postburn period, 18 piglets were submitted to an experimental study. Anaesthesia was performed by thiopentone sodium as i.v.

Haemodynamic effects of labetalol-induced hypotension in the anaesthetized dog.

Central haemodynamic changes and regional blood flow were studied using the microsphere technique, during labetalol-induced hypotension in dogs anaesthetized with pentobarbitone and fentanyl. Labetalol 15 mg kg-1 decreased mean arterial pressure from an average of 88 mm Hg to 47 mm Hg. Mean pulmonary arterial pressure was unchanged.

Deliberate arterial hypotension in plastic surgery for the reduction of hypertrophic breast: a critical appraisal of surgical ischaemia and haemodynamic changes during sodium nitroprusside infusion.

Deliberate hypotension was used to attain surgical haemostasis in thirteen patients undergoing plastic and reconstructive surgery on breast, with an 0.01% sodium nitroprusside (SNP) infusion and concomitant deep neuroleptanaesthesia. The mean surgical haemorrhage was 217 ml in the hypotensive group and when compared with a group of 13 normotensive patients, in whom the average blood loss was 688 ml, the difference was highly significant.

Ketamine infusions: pharmacokinetics and clinical effects.

The clinical effects and pharmacokinetics of ketamine, administered as an i.v. infusion, were studied in 31 patients.

Haemostatic effect of triglycylvasopressin on bleeding from gastric mucosal lesions in the rat.

The haemostatic effect of triglycylvasopressin (TGLVP) on the gastric mucosa was evaluated in an experimental model in the rat. TGLVP was found to reduce the bleeding significantly compared with the untreated controls. The haemostatic effect was most prounounced and prolonged when 200 microgram/kg b.

The effect of halothane on the distribution of cardiac output and organ blood flow in the hypovolemic dog.

The circulatory effect of halothane anesthesia given to moderately hypovolemic dogs (blood loss 25 ml/kg b.w.) was investigated using the radioactive microsphere technique.

The effect of halothane on the distribution of cardiac output and organ blood flows in the hemorrhagic, hypotensive dog.

Halothane was given to dogs which had been bled to an arterial mean blood pressure of 60 mmHg, and the circulatory effects were studied with the aid of the radioactive microsphere technique. The cardiac output and coronary blood flow were well maintained, whereas the arterial mean blood pressure was slightly, and the stroke volume markedly increased, indicating an improved heart function. The blood flows to the brain, lungs, liver and kidneys were well preserved throughout the anesthesia.

The hemodynamic effect of halothane in the normovolemic dog.

With the aid of radioactive microspheres (labeled with 169Yb, 85Sr and 141Ce, respectively), the effect of halothane anesthesia on circulation was studied for 30 min and (group A) for 120 min of halothane anesthesia in thiopental-sedated dogs. Measurements were also carried out on recovery from halothane anesthesia. Besides such well-known general circulatory changes as reduction in cardiac output, pulse rate, left ventricular work, arterial mean blood pressure and left atrial mean blood pressure, in both groups there was also a reduced coronary blood flow.

Hemodynamics during superficial thiopental anesthesia in the dog.

Radioactive microspheres, labeled withe ytterbium (169Yb), strontium (85Sr) and cerium (141Ce) were used in an investigation of the cardiovascular response to superficial thiopental anesthesia. The course was followed for 90 min and measurements were carried out 30, 60 and 90 min, respectively. Between 30 and 60 min of anesthesia there was a slight decrease in cardiac output and left ventricular work.

Distribution of cardiac output in burned mice after treatment with triglycylvasopressin.

Earlier published results have shown an increased 5-day survival in burned mice treated with Triglycylvasopressin. In order to analyze the cause of the increased survival, the distribution of cardiac output was studied in 51 mice divided into three groups. The investigation was performed on the 5th day after burn using a soluble indicator technique (86Rb).

Studies on methods for determination of the distribution of cardiac output in the mouse.

Different techniques for determining cardiac output distribution in the mouse have been studied. The soluble indicator technique using injection of rubidium on the right side of the heart was found to give a satisfactory reproducibility which made it possible to determine cardiac output fractions in the normal mouse. The use of radioactivity-labelled microspheres, which must be injected on the side of the heart, was found to give unreliable and non-reproducible results.