Benefits of combining supersaturating and solubilizing formulations - Is two better than one?

A variety of enabling formulations has been developed to address poor oral drug absorption caused by insufficient dissolution in the gastrointestinal tract. As the in vivo performance of these formulations is a result of a complex interplay between dissolution, digestion and permeation, development of suitable in vitro assays that captures these phenomena are called for. The enabling-absorption (ENA) device, consisting of a donor and receiver chamber separated by a semipermeable membrane, has successfully been used to study the performance of lipid-based formulations.

Achieving Molecular Sieving of CO from CH by Controlled Dynamical Movement and Host-Guest Interactions in Ultramicroporous VOFFIVE-1-Ni by Pillar Substitution.

Engineering the building blocks in metal-organic materials is an effective strategy for tuning their dynamical properties and can affect their response to external guest molecules. Tailoring the interaction and diffusion of molecules into these structures is highly important, particularly for applications related to gas separation. Herein, we report a vanadium-based hybrid ultramicroporous material, VOFFIVE-1-Ni, with temperature-dependent dynamical properties and a strong affinity to effectively capture and separate carbon dioxide (CO) from methane (CH).

Pharmaceutical Quality by Design Approach to Develop High-Performance Nanoparticles for Magnetic Hyperthermia.

Magnetic hyperthermia holds significant therapeutic potential, yet its clinical adoption faces challenges. One obstacle is the large-scale synthesis of high-quality superparamagnetic iron oxide nanoparticles (SPIONs) required for inducing hyperthermia. Robust and scalable manufacturing would ensure control over the key quality attributes of SPIONs, and facilitate clinical translation and regulatory approval.

Impact of polymer chemistry on critical quality attributes of selective laser sintering 3D printed solid oral dosage forms.

The aim of this study is to investigate the influence of polymer chemistry on the properties of oral dosage forms produced using selective laser sintering (SLS). The dosage forms were printed using different grades of polyvinyl alcohol or copovidone in combination with indomethacin as the active pharmaceutical ingredient. The properties of the printed structures were assessed according to European Pharmacopoeia guidelines at different printing temperatures and laser scanning speeds in order to determine the suitable printing parameters.

Plasma degradation of contaminated PPE: an energy-efficient method to treat contaminated plastic waste.

The use of PPE has drastically increased because of the SARS-CoV-2 (COVID-19) pandemic as disposable surgical face masks made from non-biodegradable polypropylene (PP) polymers have generated a significant amount of waste. In this work, a low-power plasma method has been used to degrade surgical masks. Several analytical techniques (gravimetric analysis, scanning electron microscopy (SEM), attenuated total reflection-infra-red spectroscopy (ATR-IR), x-ray photoelectron spectroscopy (XPS), thermogravimetric analysis/differential scanning calorimetry (TGA/DSC) and wide-angle x-ray scattering (WAXS)) were used to evaluate the effects of plasma irradiation on mask samples.

In situ thermal image analysis of selective laser sintering for oral dosage form manufacturing.

Additive Manufacturing (AM) is a fast-growing approach to produce personalized oral dosage forms. Even though some AM technologies are promising as alternative to conventional compounding with resulting dosage manipulation, they still suffer from a lack of quality control. Due to the high regulatory demands and standards applied to dosage forms in the case of dose accuracy and tablet properties such as friability, effective quality control is a key feature in promoting AM as a valid technology for patient-tailored medications.

Gold-iron oxide (Au/FeO) magnetic nanoparticles as the nanoplatform for binding of bioactive molecules through self-assembly.

Nanomedicine plays a crucial role in the development of next-generation therapies. The use of nanoparticles as drug delivery platforms has become a major area of research in nanotechnology. To be effective, these nanoparticles must interact with desired drug molecules and release them at targeted sites.

Selective laser sintering additive manufacturing of dosage forms: Effect of powder formulation and process parameters on the physical properties of printed tablets.

Large batches of placebo and drug-loaded solid dosage forms were successfully fabricated using selective laser sintering (SLS) 3D printing in this study. The tablet batches were prepared using either copovidone (N-vinyl-2-pyrrolidone and vinyl acetate, PVP/VA) or polyvinyl alcohol (PVA) and activated carbon (AC) as radiation absorbent, which was added to improve the sintering of the polymer. The physical properties of the dosage forms were evaluated at different pigment concentrations (i.

A hexagon based Mn(II) rod metal-organic framework - structure, SF gas sorption, magnetism and electrochemistry.

A manganese(II) metal-organic framework based on the hexatopic hexakis(4-carboxyphenyl)benzene, cpb: [Mn(cpb)(dmf)], was solvothermally prepared showing a Langmuir area of 438 m g, rapid uptake OF sulfur hexafluoride (SF) as well as electrochemical and magnetic properties, while single crystal diffraction reveals an unusual rod-MOF topology.

Low-concentration CO capture using metal-organic frameworks - current status and future perspectives.

The ever-increasing atmospheric CO level is considered to be the major cause of climate change. Although the move away from fossil fuel-based energy generation to sustainable energy sources would significantly reduce the release of CO into the atmosphere, it will most probably take time to be fully implemented on a global scale. On the other hand, capturing CO from emission sources or directly from the atmosphere are robust approaches that can reduce the atmospheric CO concentration in a relatively short time.

Chiral Lanthanum Metal-Organic Framework with Gated CO Sorption and Concerted Framework Flexibility.

A metal-organic framework (MOF) based on lanthanum(III) and the conformationally chiral linker 1,2,3,4,5,6-hexakis(4-carboxyphenyl)benzene, cpb: [La(cpb)]·1.5dmf was prepared by the solvothermal method in dimethylformamide (dmf) and characterized by variable-temperature X-ray powder diffraction (VTPXRD), variable-temperature X-ray single-crystal diffraction (SCXRD), and thermogravimetric analysis (TGA). is a rod-MOF with new topology .

3D-Printed Mesoporous Carrier System for Delivery of Poorly Soluble Drugs.

Fused deposition modelling (FDM) is the most extensively employed 3D-printing technique used in pharmaceutical applications, and offers fast and facile formulation development of personalized dosage forms. In the present study, mesoporous materials were incorporated into a thermoplastic filament produced via hot-melt extrusion and used to produce oral dosage forms via FDM. Mesoporous materials are known to be highly effective for the amorphization and stabilization of poorly soluble drugs, and were therefore studied in order to determine their ability to enhance the drug-release properties in 3D-printed tablets.

Catalytic cracking of Etek lignin with zirconia supported metal-oxides for alkyl and alkoxy phenols recovery.

Alkyl and alkoxy phenols are desirable products from the catalytic depolymerisation of lignin. In this work, ex-situ catalytic pyrolysis of Etek lignin in presence of Na, Ce, NiCe, MgCe, Fe and FePd on ZrO was studied The largest combined yield of monomeric phenolics and alkylphenols was produced by Na/ZrO catalysts. A parametric study of the most promising Na/ZrO then resulted in using a catalyst:lignin ratio of 3:1 at 500 °C as the best option, enhancing at 17.

In Vitro Performance and Chemical Stability of Lipid-Based Formulations Encapsulated in a Mesoporous Magnesium Carbonate Carrier.

Lipid-based formulations can circumvent the low aqueous solubility of problematic drug compounds and increase their oral absorption. As these formulations are often physically unstable and costly to manufacture, solidification has been suggested as a way to minimize these issues. This study evaluated the physicochemical stability and in vitro performance of lipid-loaded mesoporous magnesium carbonate (MMC) particles with an average pore size of 20 nm.

Highly Porous Amorphous Calcium Phosphate for Drug Delivery and Bio-Medical Applications.

Amorphous calcium phosphate (ACP) has shown significant effects on the biomineralization and promising applications in bio-medicine. However, the limited stability and porosity of ACP material restrict its practical applications. A storage stable highly porous ACP with Brunauer-Emmett-Teller surface area of over 400 m/g was synthesized by introducing phosphoric acid to a methanol suspension containing amorphous calcium carbonate nanoparticles.

Nanoparticle-loaded hydrogels as a pathway for enzyme-triggered drug release in ophthalmic applications.

The aim of this study was to develop nanoparticle loaded hydrogel based contact lenses that could be used for ocular drug delivery. Two potential contact lens platforms for controlled ophthalmic drug delivery were developed by incorporating chitosan-poly (acrylic acid) nanoparticles into polyvinyl alcohol (PVA) hydrogels and in-situ gelled nanoparticles and cellulose nanocrystals (CNC) in PVA lenses. The nanoparticles were shown to disintegrate in a physiological 0.