NEOADJUVANT TREATMENT OF LIVER METASTASES OF COLORECTAL CANCER: PREDICTIVE FACTORS OF PATHOLOGICAL RESPONSE.

Background: Surgery after neoadjuvant chemotherapy (CT) improves the prognosis of colorectal liver metastases (CRLM).

Aims: The aim of this study was to evaluate the predictive factors of the histological response of CRLM after neoadjuvant treatment.

Methods: A retrospective monocentric study including patients with CRLM operated after neoadjuvant treatment.

Computed Tomographic presentation of obstructive jejunal adenocarcinoma associated with celiac disease and incomplete intestinal malrotation.

Introduction: Small bowel adenocarcinoma is a rare entity most frequently observed with celiac disease. This is the first case report on the association of celiac disease, small bowel adenocarcinoma and intestinal malrotation.

Case Report: A 40 year-old male patient diagnosed with celiac disease since the age of 5 years complained of epigastric pain and vomiting for three days.

[Review of 32 gastro-intestinal stromal tumours with CD117 antigen].

Aim: The aim of this study is to review clinical data, histological and immunohistochemical findings and prognosis of stromal gastrointestinal tumors.

Methods: A retrospective Study of 32 cases of stromal gastrointestinal tumors diagnosed in the Department of Pathology of Mongi Slim Hospital of Tunis from 1991 to 2004.

Results: The average age of the patients was of 54.

[Lethal osteo-chondro-dysplasia: feto-pathological study of 32 cases].

Background: The lethal osteochondrodysplasias are rare, their prevalence is estimated at 1 per 10 000 births. Mostly have genetic determinism.

Aims: To describe the malformations and dysmorphic features in lethal osteochondrodysplasias

Methods: Our study involved 32 cases of lethal fetal Osteochondrodysplasias, collected over a period of 14 years in the pathological department of Sousse.

[Holoprosencephaly: foetopathologic study of 15 cases].

Background: Holoprosencephaly (HPE) is a rare and serious brain anomaly of heterogeneous aetiology.

Aims: description of neuropathologic patterns of HPE to eventually integrate it into recognized syndrome

Methods: The authors report 15 cases of HPE, examined at the department of pathology of Sousse (Tunisia) over a period of 11 years.

Results: The average age of mothers was 32 years and 46% of them were primigestes.

Schneckenbecken dysplasia in fetus: report of four cases.

Several different types of lethal short-limbed skeletal dysplasia with platyspondylia have been recognized with a different mode of inheritance. Schneckenbecken dysplasia, a very rare lethal osteochondrodysplasia, is included in these entities, with an autosomal recessive mode of inheritance. We describe 4 new Tunisian cases with clinical, radiographic and histopathological features.

[An uncommon trichoepithelioma: the giant solitary trichoepithelioma].

A case of giant solitary trichoepithelioma of the perianal region is described so to draw attention to this rare benign neoplasme and to discuss its clinical and histopathological chracteristics.

[Inflammatory fibroid polyp of the ileum presenting as intussusception: a case report in an adolescent].

Inflammatory fibroid polyp is an uncommon and benign submucosal lesion of the gastrointestinal tract. The maximal incidence is in the fifth and sixth decades. The main histological characteristics are diffuse inflammatory infiltrate with eosinophils and highly vascularized fibrocystic stroma.

[Hepatic mesenchymal hamartoma in adulthood: a case report with literature review].

Mesenchymal hamartoma is a rare and benign tumor.. Representing 5 to 8 % of children's hepatic tumors, it is rarely described in adults.

[Malignant degeneration of mature benign teratoma of the ovary: a case report].

Malignant transformation of ovarian mature benign teratomas is an uncommon complication which often occurs in the postmenopausal period. Clinical presentation is similar to that of benign ovarian cysts. The diagnosis of malignant transformation is often made per-operatively by the break of the capsule and the adhesions of the tumor or during histological examination.

[Intestinal T cell lymphoma in coeliac disease. A case report].

Primary intestinal T-cell lymphomas account for about 5% of all primary gastrointestinal lymphomas and are mostly associated with coeliac disease. Intestinal lymphomas are usually discovered during the 4th to 5th decade and constitute an exceptional complication of coeliac disease. This lymphoma is generally a high grade pleomorphic cell lymphoma with large cells.

[Kikuchi disease: an unusual clinico-pathologic presentation].

Histiocytic necrotizing lymphadenitis, also known as KIKUCHI disease is rare self-limited condition of young adults. Manifestations include enlargements of the cervical lymph nodes, sometimes with fever, and can be associated with other non-specific signs. The aetiologie of this affection is still unclear.