Evaluation of Efficacy and Safety of Empagliflozin in Bangladeshi Patients with Type 2 Diabetes Mellitus (EFFISAEM Study).

Background: Empagliflozin is a relatively newer glucose-lowering drug (GLD) with many extra-glycemic benefits. To date, no study has evaluated the efficacy and safety of empagliflozin in Bangladeshi patients with type 2 diabetes mellitus (T2DM).

Objectives: To assess the efficacy and safety of empagliflozin as an add-on to ongoing GLDs in Bangladeshi adults with uncontrolled T2DM.

Role of Obeticholic Acid, a Farnesoid X Receptor Agonist, in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis.

Obeticholic acid (OCA) has emerged as a promising drug in the management of nonalcoholic fatty liver disease (NAFLD). This meta-analysis aimed to analyse the therapeutic effect of OCA on NAFLD. Randomized controlled trials (RCTs) involving patients with NAFLD receiving OCA in the intervention arm and placebo in the control arm were searched throughout the electronic databases.

Status of lipid control in Bangladeshi subjects with type 2 diabetes mellitus on lipid-lowering drugs: a multicenter, facility-based, cross-sectional study.

Background: Achievement of lipid targets is crucial in patients with type 2 diabetes mellitus (T2DM) to mitigate the risk of cardiovascular diseases (CVD). Data on lipid-control status among patients with T2DM in Bangladesh are scarce. This study was conducted to determine the lipid-control status among patients with T2DM who were on lipid-lowering drugs in the country.

Comparison of fasting and random lipid profiles among subjects with type 2 diabetes mellitus: an outpatient-based cross-sectional study in Bangladesh.

Background: Despite the wide acceptability of fasting lipid profiles in practice, emerging evidence suggests that random lipid profiles might be a convenient alternative for lipid measurement. The objective of the present study was to compare the fasting and random lipid profile among subjects with type 2 diabetes mellitus (T2DM).

Methods: The present cross-sectional study included 1543 subjects with T2DM visiting several endocrinology outpatient clinics throughout Bangladesh from January to December 2021.

Economic Burden of Severe Hypoglycemia Among Patients With Diabetes Mellitus.

Background: Bangladesh is anticipated to have the eighth-highest number of diabetic patients within the next 15 years. Approximately one-fifth of adult diabetes patients reside in Southeast Asian nations. This study aimed to find out the economic burden of extreme hypoglycemia on diabetic sufferers in Bangladesh.

Assessment of Failure Rate of Fixed Partial Dentures: A Clinical Study.

Introduction: The most common for the replacement for the teeth are the partial dentures. Hence, in our study, we analyzed the failure rates of the fixed partial dentures (FPDs).

Materials And Methods: We conducted a retrospective study from the institutional record and analyzed 150 subjects.

Hypothetical protein predicted to be tumor suppressor: a protein functional analysis.

Litorilituus sediminis is a Gram-negative, aerobic, novel bacterium under the family of Colwelliaceae, has a stunning hypothetical protein containing domain called von Hippel-Lindau that has significant tumor suppressor activity. Therefore, this study was designed to elucidate the structure and function of the biologically important hypothetical protein EMK97_00595 (QBG34344.1) using several bioinformatics tools.

Prevalence of Subclinical Hypothyroidism in Hospitalized Pre-dialysis Patients with Chronic Kidney Disease.

Among general population sub-clinical primary hypothyroidism is common. The cross sectional descriptive type of observational study was conducted in medicine and allied wards in Mymensingh Medical College Hospital, Mymensingh, Bangladesh from January 2010 to December 2010; among 230 purposively selected hospitalized pre-dialysis patients with chronic kidney disease. The purpose of the study was to find out the prevalence of sub-clinical hypothyroidism in hospitalized pre-dialysis patients with chronic kidney disease.

The Burden of Severe Hypoglycemia on Quality of Life among Diabetes Mellitus Patients in a Tertiary Level Hospital of Bangladesh.

Objective: This study aimed to determine the impact of hypoglycemia on health-related quality of life from a patient perspective.

Materials And Methods: A cross-sectional study was conducted in 164 type 2 diabetes patients admitted due to severe hypoglycemia from August 2015 to October 2016 at Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders, in Dhaka. Impact of severe hypoglycemia on health-related quality of life in diabetic patients was evaluated using the disease-specific questionnaire audit of diabetes-dependent quality of life-19 (ADDQOL-19).

Post-retention Development of Curve of Spee in Pre-adjusted Edgewise Appliance Cases, Its Correlation to Dentoskeletal Parameters: An In vitro Study.

Background: Curve of Spee was first described by Ferdin and Graf Von Spee in 1890. The curve of Spee is an important characteristic of the mandibular dental arch. One of the most frequently encountered problems in the treatment of orthodontic patients is an excessive overbite.

Knowledge and attitude of patients toward dental implants as an option for replacement of missing teeth.

Objective: The present study was undertaken to access the level of knowledge and attitude of patients toward implant treatment as an option for replacement of missing teeth.

Materials And Methods: An epidemiological study was conducted among 440 subjects who attended the OPD of two Departments (Prosthodontics and Oral and Maxillofacial Surgery). A self-administered structured closed ended questionnaire pretested through a pilot survey was used in the study.

Prevalence of malocclusion among 12 to 15 years age group orphan children using dental aesthetic index.

Objective: The study was done to determine the prevalence of malocclusion and orthodontic treatment among orphan children.

Materials And Methods: The sample consisted of 165 orphan children aged between 12 and 15 years. A clinical examination was used to determine the orthodontic treatment need according to the Dental Aesthetic Index (DAI).

Maxillomandibular plane angle bisector (MM) adjunctive to occlusal plane to evaluate anteroposterior measurement of dental base.

Aim: This study was undertaken to analyze the clinical usefulness of the maxillomandibular bisector, its reproducibility, its validity and its relationship to the functional occlusal plane, the bisecting occlusal plane and the nature of its cant.

Materials And Methods: Thirty pretreatment lateral cephalograms, each of adolescents (above 18 years of age) and children (10- 12 years), seeking orthodontic treatment were randomly selected and the Wits technique of anteroposterior measurement was used to compare A-B values measured to the new plane with those measured to the functional occlusal plane (FOP) and to the traditional or bisecting occlusal plane (BOP).

Results: Present study showed that MM bisector plane is more reproducible and valid reference plane, than the FOP and BOP.