Publications by authors named "Aham Okorozo"
Article Synopsis
- Basal cells (BCs) are important for regenerating damaged airways but can transform into cancerous cells in smokers; this study investigates BC growth in smokers and non-smokers without cancer, as well as in those with lung cancer.
- Researchers used techniques like RNA sequencing and flow cytometry to analyze BCs from endobronchial samples, focusing on differences in cell growth, shape, and molecular characteristics between various donor groups.
- Results showed that smoking decreased BC proliferation, increased abnormal cell shapes in certain cancers, and highlighted changes in gene expression linked to cell behavior and signaling pathways that may contribute to early lung cancer development.
Straight-back syndrome is a rare congenital condition involving the loss of the normal dorsal curvature of the upper thoracic spine. This leads to flattening of the upper thoracic cavity, resulting in compression of the underlying vasculature and airways. In this case report, we discuss the management of an 18-year-old male with straight-back syndrome who was referred to our interventional pulmonary clinic for further management of his stridor and apneic events.
View Article and Find Full Text PDFLung diseases, including lung cancer, are rising causes of global mortality. Despite novel imaging technologies and the development of biomarker assays, the detection of lung cancer remains a significant challenge. However, the lung communicates directly with the external environment and releases aerosolized droplets during normal tidal respiration, which can be collected, stored and analzsed as exhaled breath condensate (EBC).
View Article and Find Full Text PDFA Case Report of Kidney After Heart Transplant in Patient With Fabry Disease.
Transplant Proc
October 2023
Fabry disease is an X-linked inherited lysosomal storage disorder caused by a mutation in the gene encoding the enzyme α-galactosidase A. It is characterized by the accumulation of globotriaosylceramide in different tissues, resulting in a wide range of clinical presentations. Fabry cardiomyopathy and Fabry nephropathy are the disease's 2 most important life-threatening manifestations and can contribute to higher morbidity and mortality.
View Article and Find Full Text PDFBackground: Although the burden of neurological disorders is highest among populations in developing countries there is a dearth of data on the clinical spectrum of these disorders.
Objective: To profile the frequency of neurologic disorders and basic demographic data in an adult neurology out-patient service commissioned in 2011 in Kumasi, Ghana.
Methods: The study was conducted at the neurology clinic of the Komfo Anokye Teaching Hospital in Kumasi, Ghana.