Prediction of renal and cardiometabolic outcomes in gout during urate-lowering therapy by sonography.

Objectives: To assess whether the extent of monosodium urate (MSU) crystal deposition estimated by ultrasound could predict renal and cardiometabolic events during urate-lowering therapy (ULT).

Methods: A prospective study on gout patients from two referral centers initiating ULT who underwent baseline ultrasound and were followed for 1 year. Ultrasound scans assessed six joints for double-contour (DC) signs and tophi.

Sonographic Tophi and Inflammation Are Associated With Carotid Atheroma Plaques in Gout.

Gout and cardiovascular disease are closely related, but the mechanism connecting them remains unknown. This study aims to explore whether urate crystal deposits and inflammation (assessed by ultrasound) are associated with carotid atherosclerosis. We included consecutive patients with crystal-proven gout newly presenting to a tertiary rheumatology unit.