Publications by authors named "Agus Susanto Kosasih"
Article Synopsis
- Cytogenetics plays a critical role in diagnosing and predicting outcomes for myelodysplastic syndrome (MDS), with specific profiles indicating a higher risk of progression to acute myeloid leukemia (AML).
- This study focused on Indonesian patients with MDS, assessing their cytogenetic profiles through clinical examinations and follow-ups over one year.
- Key findings included the identification of monosomy 7 and chromosome 5 deletions in certain patients, along with a notable risk of AML transformation in those with MDS-EB.
Objective: Acute Lymphoblastic Leukemia (ALL) is the most common malignancy occurring in children. Copy number alterations (CNA) like PAX5, CDKN2A/2B, PAR1 Region, ETV6, IKZF1, BTG1, and RB1 gene deletion are important genetic events that define and prognosticate B-cell ALL. Thus, this study aimed to evaluate associations of CNA with induction phase remission status in childhood B-cell ALL.
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- - The study evaluated the performance of the Bioneer AccuPower® HIV-1 Quantitative RT-PCR kit by comparing it to the established Roche COBAS® AmpliPrep/COBAS® TaqMan® HIV-1 test using 288 plasma samples.
- - Results showed a strong correlation between the two assays, with high agreement (94.9%) and a mean difference of only 0.11 Log10 IU/mL, indicating reliability in measurements.
- - The findings suggest that the Bioneer assay is a viable option for quantifying HIV-1 RNA in clinical settings, supporting its use in therapeutic strategy development.