The gut-brain axis is a bidirectional communication pathway that modulates cognitive function. A dysfunctional gut-brain axis has been associated with cognitive impairments during aging. Therefore, we propose evaluating whether modulation of the gut microbiota through fecal microbiota transplantation (FMT) from young-trained donors (YT) to middle-aged or aged mice could enhance brain function and cognition in old age.
View Article and Find Full Text PDFThis study characterized toothache-related Portuguese Facebook posts, identifying factors driving misinformation production and user engagement. Investigators qualitatively analyzed 500 posts published between August 2018 and August 2022, screening on language and theme. Posts were selected using CrowdTangle and assessed for motivation, author profile, content, sentiment, facticity, and format.
View Article and Find Full Text PDFEur Arch Paediatr Dent
November 2024
Purpose: To determine the interests of Google users from different countries about pacifier-related information over time, through a quantitative and qualitative analysis.
Methods: This infodemiology longitudinal retrospective ecological study investigated pacifier-related computational metadata from 22 countries using Google Trends platform. Initially, Relative Search Volume (RSV) time series data and their respective main queries were collected employing the topic "pacifier - subject" as the search strategy from January 2004 to June 2024, considering all categories.
We construct a set of new epidemiological thresholds to address the general problem of spreading and containment of a transmissible disease with influx of infected individuals (i.e., when the classic R is no longer meaningful).
View Article and Find Full Text PDFThe Big Five personality traits have shown associations with symptoms of depression and anxiety among college students, but it is unclear which factors mediate these relationships. Past research suggests that psychological distress is closely related to difficulties in affect regulation (e.g.
View Article and Find Full Text PDFActa Trop
July 2024
Malaria remains a highly prevalent infectious disease worldwide, particularly in tropical and subtropical regions. Effectively controlling of mosquitoes transmitting of Plasmodium spp. is crucial in to control this disease.
View Article and Find Full Text PDFStudies on the impact of the COVID-19 pandemic in sub-Saharan Africa have yielded varying results, although authors universally agree the real burden surpasses reported cases. The primary objective of this study was to determine SARS-CoV-2 seroprevalence among patients attending Monkole Hospital in Kinshasa (D.R.
View Article and Find Full Text PDFTrichinellosis is a foodborne disease caused by ingestion of raw or undercooked meat containing Trichinella spp. larvae. Consumption of wild boar (Sus scrofa) meat represents an important source of human trichinellosis worldwide.
View Article and Find Full Text PDFThe Internet is a growing source of knowledge and can provide information about oral health. This ecological study aimed to characterize the interests in toothpaste among Google users from different countries. Our hypothesis was that there would be an increase in Google users' interest in information about toothpaste.
View Article and Find Full Text PDFBackground: It is uncertain whether individualisation of the perioperative open-lung approach (OLA) to ventilation reduces postoperative pulmonary complications in patients undergoing lung resection. We compared a perioperative individualised OLA (iOLA) ventilation strategy with standard lung-protective ventilation in patients undergoing thoracic surgery with one-lung ventilation.
Methods: This multicentre, randomised controlled trial enrolled patients scheduled for open or video-assisted thoracic surgery using one-lung ventilation in 25 participating hospitals in Spain, Italy, Turkey, Egypt, and Ecuador.
Tuberculosis (TB) is a major cause of morbidity and mortality worldwide. The emergence and rapid spread of drug-resistant M. tuberculosis strains urge us to develop novel treatments.
View Article and Find Full Text PDFEur Arch Paediatr Dent
December 2023
Purpose: To assess the coverage of information about early childhood caries (ECC) available on YouTube videos in three different languages, regarding technical characteristics of videos and interaction metrics.
Methods: Search strategies were developed in English, Spanish, and Portuguese to make a comprehensive collection of videos from YouTube, encompassing 60 samples for each language, regarding all video types. The videos were assessed by a thematic checklist regarding 17 items on ECC.
The utilization of simulation has proved to be a valuable tool to train students in the academic setting in preparation for the clinical environment. Student registered nurse anesthetists (SRNAs) receive limited education and training on the use of powered air-purifying respirators when caring for patients with highly infectious diseases (i.e.
View Article and Find Full Text PDFThis article explores the question of why the nine pandemics prior to COVID-19 - which have affected millions of people since the second half of the 20th century - were not recorded in collective memory despite their magnitude and extent. Thus, it proposes a reading of the pandemic as one component of a wider syndemic made up of contagious diseases, climate change, and malnutrition. This piece offers a narrative of the origins, development, and prospects of the pandemic within the dynamics of the global food system and national economic and political systems, highlighting components and connections.
View Article and Find Full Text PDFIron absorption is a complex and highly controlled process where DMT1 transports nonheme iron through the brush-border membrane of enterocytes to the cytoplasm but does not transport alkaline-earth metals such as calcium. However, it has been proposed that high concentrations of calcium in the diet could reduce iron bioavailability. In this work, we investigate the effect of intracellular and extracellular calcium on iron uptake by Caco-2 cells, as determined by calcein fluorescence quenching.
View Article and Find Full Text PDFRev Psiquiatr Salud Ment
October 2022
Adaptation and microbial attachment mechanisms for the degradation of sulfide ores are mediated by the production of extracellular polymeric substances (EPS) and their role in biofilm formation. EPS production responds to induction mechanisms associated with environmental conditions. In this study, the double induction of EPS with galactose and high ferric iron concentrations in planktonic cells of , and their attachment on the surface of a polymetallic sulfide ore from Bella Rica-Azuay in Ecuador were evaluated.
View Article and Find Full Text PDFThis study evaluated the behavior of Internet users from seven countries through the analysis of the monthly variation of the Relative Search Volume (RSV) for queries related to early childhood caries (ECC), retrieved by Google Trends application programming interface between January 2004 to December 2020. The association of RSV with years lived with disability (YLDs) for untreated dental caries in deciduous teeth and Internet penetration were tested by regression models. Forecasting models were developed to predict the interests until December 2021.
View Article and Find Full Text PDFTo mitigate the unprecedented health, social, and economic damage of COVID-19, the Philippines is undertaking a nationwide vaccination program to mitigate the effects of the global pandemic. In this study, we interrogated COVID-19 vaccine intent in the country by deploying a nationwide open-access online survey, two months before the rollout of the national vaccination program. The Health Belief Model (HBM) posits that people are likely to adopt disease prevention behaviors and to accept medical interventions like vaccines if there is sufficient motivation and cues to action.
View Article and Find Full Text PDFNeuroblastoma is a type of cancer intimately related with early development and differentiation of neuroendocrine cells, and constitutes one of the pediatric cancers with higher incidence and mortality. Protein tyrosine phosphatases (PTPs) are key regulators of cell growth and differentiation by their direct effect on tyrosine dephosphorylation of specific protein substrates, exerting major functions in the modulation of intracellular signaling during neuron development in response to external cues driving cell proliferation, survival, and differentiation. We review here the current knowledge on the role of PTPs in neuroblastoma cell growth, survival, and differentiation.
View Article and Find Full Text PDFIntroduction: Use of Social networking sites (SNSs) is a highly prevalent behavior worldwide and, for some individuals, its use can turn maladaptive. There has been growing interest to identify which variables are associated with problematic use of SNSs.
Aim: The present study cross-sectionally examined whether the associations between different features of self-control (i.
Various strategies to accelerate the formation of biofilms on minerals have been studied, and one of them is the use of D-galactose as an inducer of EPS production in planktonic cells of biooxidant bacteria. With the aim to evaluate the influence on the attachment and the effect over the solubilization of a polymetallic mineral concentrate, the behavior of a microbial consortium formed by DSM 14887 and DSM 2705 previously induced with D-galactose for the early formation of EPS was studied. These microorganisms were previously adapted to 0.
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