Modeling scalability of impurity precipitation in downstream biomanufacturing.

Precipitation during the viral inactivation, neutralization and depth filtration step of a monoclonal antibody (mAb) purification process can provide quantifiable and potentially significant impurity reduction. However, robust commercial implementation of this unit operation is limited due to the lack of a representative scale-down model to characterize the removal of impurities. The objective of this work is to compare isoelectric impurity precipitation behavior for a monoclonal antibody product across scales, from benchtop to pilot manufacturing.

Does cannabis affect cognitive functioning in patients with schizophrenia?

Introduction: Cannabis use impairs cognitive performance in healthy subjects; several studies have shown improved cognitive outcomes in schizophrenic patients using cannabis. The aim of this study was to evaluate the effects of cannabis use on cognitive function in Moroccan patients with schizophrenia who were cannabis users.

Method: Two groups were recruited in a Moroccan University Psychiatric Centre.

Associative learning and facial expression recognition in schizophrenic patients: Effects of social presence.

Schizophrenia (SCZ) is a psychiatric disorder that alters both general and social cognition. However, the exact mechanisms that are altered remain to be elucidated. In this study, we investigated associative learning (AL) and facial expression recognition (FER) in the same patients, using emotional expressions and abstract images.

Natural adaptation and human selection of northeast African sheep genomes.

African sheep manifest diverse but distinct physio-anatomical traits, which are the outcomes of natural- and human-driven selection. Here, we generated 34.8 million variants from 150 indigenous northeast African sheep genomes sequenced at an average depth of ∼54× for 130 samples (Ethiopia, Libya) and ∼20× for 20 samples (Sudan).

[Factors associated with the risk of developing eating disorders among medical students in Casablanca, Morocco].

Introduction: eating disorders (EDs) are particularly common among young adults, including students. The purpose of this study is to determine eating disorder prevalence among medical students in Casablanca and to assess the risk of developing EDs on the bases of associated factors including socioeconomic factors, clinical features, anxiety and depression.

Methods: we conducted a cross-sectional, descriptive and analytical study at the Ibn Rochd University Hospital and at the Faculty of Medicine and Pharmacy of Casablanca, Morocco, during the academic year 2016-2017.

COVID-19: Patient care after discharge from the Intensive Care Unit.

Introduction: The Ibn Rochd CHU is a tertiary care structure that provides care for the most severe cases of COVID-19 requiring hospitalisation in intensive care. The objective of study is to describe the complementary medical and psychological care of patients with COVID-19 in the endocrinology department after a stay in intensive care.

Patients And Methods: This is a descriptive observational study of patients transferred from the intensive care unit to the endocrinology service following a COVID-19 infection during the period from 17 April 2020 to May 26, 2020.

Real-Time Monitoring System to Manage Mental Healthcare Emergency Unit.

Objectives: Real-time relevant information helps guide the healthcare decision-making process in daily clinical practice as well as the management and optimization of healthcare processes. However, proprietary business intelligence suite solutions supporting the production of decision-making information requires investment that is out of reach of small and mediumsized healthcare facilities or those with limited resources, particularly in developing countries. This paper describes our experience in designing and implementing a real-time healthcare monitoring system solution to manage healthcare emergency units.

Monitoring Mental Healthcare Services Using Business Analytics.

Objectives: Monitoring healthcare activities is the first step for health stakeholders and health professionals to improve the quality and performance of healthcare services. However, monitoring remains a challenge for healthcare facilities, especially in developing countries. Fortunately, advances in business analytics address this need.

How service users and carers understand, perceive, rephrase, and communicate about "depressive episode" and "schizophrenia" diagnoses: an international participatory research.

Background: For ICD-11, the WHO emphasized the clinical utility of communication and the need to involve service users and carers in the revision process.

Aims: The objective was to assess whether medical vocabulary was accessible, which kinds of feelings it activated, whether and how users and carers would like to rephrase terms, and whether they used diagnosis to talk about mental health experiences.

Method: An innovative protocol focused on two diagnoses (depressive episode and schizophrenia) was implemented in 15 different countries.

[Risperidone and carbamazepine-induced syndrome of inappropriate antidiuretic hormone secretion: case study].

The inappropriate antidiuretic hormone secretion Syndrome (ADHS) accounts for approximately 50% of all diagnosed cases of hyponatremia while drug-induced ADHS accounts for a small proportion of cases. We report the case of a female patient, treated for schizoaffective disorder, who developed ADHS following the initiation of risperidone and carbamazepine. Biochemical test results suggested risperidone and carbamazepine-induced ADHS.

Comparison of eosin and fluorescein conjugates for the photoinitiation of cell-compatible polymer coatings.

Targeted photopolymerization is the basis for multiple diagnostic and cell encapsulation technologies. While eosin is used in conjunction with tertiary amines as a water-soluble photoinitiation system, eosin is not widely sold as a conjugate with antibodies and other targeting biomolecules. Here we evaluate the utility of fluorescein-labeled bioconjugates to photopolymerize targeted coatings on live cells.

[Evaluation of burnout syndrome among doctors in training at the Ibn Rochd University Hospital, Casablanca].

Methods: We conducted a descriptive cross-sectional study of a sample of 300 physicians using self-administered questionnaire over the period 2013- 2014. Burnout has been operationally defined through a French translation of the Maslach Burnout Inventory (MBI).

Results: A total of 191 physicians participated in the study (response rate 63.

[Noise Effects on Mental Health: a review of literature].

Unlabelled: Any human activity generates noise. It is considered as a risk factor for people's health. The present review of literature has assessed the impact of noise on mental health; it is summarized into four points: objective, methods, results and conclusion.

Prevalence of stress in Casablanca medical students: a cross-sectional study.

Introduction: Recently, an important literature data has reported that medical students experience stress more than students in other disciplines. In contrast, there is a significant shortage of the stress impact on the academic performance. The primary purpose of our study was to determine the prevalence of stress among Casablanca Medical students and to investigate if there is an association between stress and academic skills.

[Frequency and risk factors for pathological gambling in a sample of gamblers in Casablanca, Morocco].

Introduction: Pathological gambling is a major psychiatric disorder and a public health problem that has gained a lot of attention in the last few years. The problems caused by gambling are increasingly serious. The prevalence of pathological or compulsive gambling varies from 0.

Moroccan national study on prevalence of mental disorders: a community-based epidemiological study.

Objective: The main objective of this study was to assess the prevalence of common mental disorders in the Moroccan general population.

Method: On a systematic representative randomized sample, the Moroccan Arabic version of the Mini International Neuropsychiatric Interview (MINI) was used to assess the prevalence of mood, anxiety, substance, and alcohol abuse disorders.

Results: Among 5498 subjects interviewed, 40.

Prevalence of anxiety disorders: a population-based epidemiological study in metropolitan area of Casablanca, Morocco.

Background: In Morocco, no epidemiological study has been conducted to show the current prevalence of mental disorders in the general population. The aim of the present study was to assess the prevalence and comorbidity of anxiety disorders in Moroccan subjects.

Methods: We used cross-sectional study, with a representative sample of Casablanca city.