Publications by authors named "Agostino Rodeo Sica"
Article Synopsis
- SHP-1 is found to be crucial in determining the responsive treatment of imatinib (IMA) in chronic myelogenous leukemia (CML) cells, with lower levels in resistant cells compared to sensitive ones.
- Ectopic expression of SHP-1 in resistant cell lines restores interaction with SHP-2 and improves responsiveness to IMA, while knockdown of SHP-2 reduces cell viability and STAT3 activation after treatment.
- The findings indicate that SHP-1 could serve as a potential biomarker for predicting IMA sensitivity in CML patients, as confirmed by lower SHP-1 mRNA levels in patients with treatment failures.
