Publications by authors named "Agnieszka Milewska"
Background: The European Parliament's directive on open data indicates the direction to follow for all public institutions in Europe. The portal Polish Platform of Medical Research (PPM) required more information about researcher attitudes and training requirements for strategic planning.
Objectives: The aim was to assess (1) the status of knowledge about research data management among medical researchers in Poland, and (2) their attitudes towards data sharing.
Unlabelled: Cervical uterine cancer is the second most frequent female cancer worldwide and a substantial burden for low-income societies and the patients themselves. Understanding the molecular mechanisms of metastasis permits the development of therapies that limit tumor progression, as well as providing health and social benefits. Pathomorphology is still the basis of research and a reference standard for molecular analysis.
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- Malignant melanoma shows resistance to treatment partly due to the downregulation of Apaf-1, a vital protein for triggering apoptosis.
- Research indicates a significant decline in Apaf-1 levels as melanoma progresses, particularly noted between Clark II and Clark III stages, implying its potential role in the transition to more aggressive tumor growth.
- The study suggests that monitoring Apaf-1 expression could serve as a prognostic marker for melanoma progression and supports the idea that loss of this protein might contribute significantly to melanoma development.