Studies on the Complexation of Platinum(II) by Some 4-Nitroisoxazoles and Testing the Cytotoxic Activity of the Resulting Complexes.

Two novel platinum(II) complexes ( and ) were synthesized by the reaction of the appropriate 3,5-dimethyl-4-nitroisoxazole with KPtCl and characterized by elemental analysis, ESI MS spectrometry, H NMR and far-IR spectroscopy. The structure of complex was additionally confirmed by X-ray diffraction. The cytotoxicity of the investigated compounds was examined in vitro on three human cancer cell lines (MCF-7 breast, ES-2 ovarian and A-549 lung adenocarcinomas) in both normoxia and hypoxia conditions.

Synthesis of Platinum(II) Complexes with Some 1-Methylnitropyrazoles and In Vitro Research on Their Cytotoxic Activity.

A series of eight novel platinum(II) complexes were synthesized by the reaction of the appropriate 1-methylnitropyrazole derivatives with KPtCl and characterized by elemental analysis, ESI MS spectrometry, H NMR, Pt NMR, IR and far IR spectroscopy. Thermal isomerization of -dichloridobis(1-methyl-4-nitropyrazole)platinum(II) to -dichloridobis(1-methyl-4-nitropyrazole)platinum(II) has been presented, and the structure of the compound has been confirmed by X-ray diffraction method. Cytotoxicity of the investigated compounds was examined in vitro on three human cancer cell lines (MCF-7 breast, ES-2 ovarian and A-549 lung adenocarcinomas) and their logP was measured using a shake-flask method.