Publications by authors named "Agnieszka Jarzemska"

Article Synopsis
  • Nintedanib is used to treat idiopathic pulmonary fibrosis (IPF) and this study analyzed its safety and efficacy in a large group of Polish patients from March 2018 to October 2021.* -
  • The study included 501 patients, mostly male and averaging around 71 years old, who were monitored for a median of 15 months; results showed stable pulmonary function for most, although some experienced adverse drug reactions (ADRs) like diarrhea and decreased appetite.* -
  • Overall, nintedanib was found to be safe with acceptable side effects, and the findings align with previous research on nintedanib's effectiveness in managing IPF.*
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Article Synopsis
  • Pirfenidone, an antifibrotic medication, has been used in Poland since 2017 to treat idiopathic pulmonary fibrosis (IPF), with the PolExPIR study analyzing its real-world safety and efficacy among Polish patients from January 2017 to September 2019.
  • The study identified 307 patients, with an average age of nearly 69 years, and found that many required dose adjustments; approximately 46% discontinued treatment due to various reasons, including adverse drug reactions and disease progression.
  • Overall, patients showed stable pulmonary function during the study, but there was a notable decline in lung capacity over two years, with a 10.75% mortality rate among participants.
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Fatigue is one of the most common and disabling symptoms of sarcoidosis. The cause of fatigue remains unclear and is usually multifactorial. The majority of previous studies evaluated clinical parameters with only few of them including assessment of psychological factors as contributing to the severity of the symptoms.

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Objective: The purpose of the study was to evaluate the relationship of an objective functional lung parameter (FVC) and a subjective psychological factor (physical symptom concerns) with dyspnea in sarcoidosis. Dyspnea constitutes one of the most common and burdensome symptoms in sarcoidosis, yet little is known about its mechanisms and, in particular, psychological.

Method: A total of 107 hospitalized sarcoidosis patients (Female=50, M=45.

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Rounded atelectasis of the lung is well described in medical literature, but still difficult to diagnose. Since lesions give no clinical symptoms in patients, radiologists are often the first to recognize the round lesion in an X-ray picture or a CT scan. Rounded atelectasis is an atypical form of lung collapse that usually occurs adjacent to scarred pleura and can be mistaken for lung cancer.

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The exact role of FasL, and particularly its soluble and membrane-bound forms, in the development of chronic ILDs and lung fibrosis has not been extensively explored. We aimed at analyzing membrane-bound FasL expression on alveolar macrophages (AM) and lymphocytes (AL) as well as soluble FasL (sFasL) levels in bronchoalveolar lavage (BAL) from ILDs patients, incl. pulmonary sarcoidosis (PS), hypersensitivity pneumonitis (HP), silicosis, asbestosis, idiopathic pulmonary fibrosis (IPF), nonspecific interstitial pneumonia (NSIP), and healthy subjects (n = 89, 12, 7, 8, 23, 6, 17, respectively).

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Background: Sarcoidosis is a systemic and multiorgan disease with unknown etiopathogenesis. Granulomas that do not undergo necrosis and caseous degeneration are distinctive for this disease. Mostly it is connected with young adults, more frequently females than males, and changes are mainly situated in the lymph nodes of the pulmonary hilus and pulmonary parenchyma.

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Dermatomyositis (DM) is a connective tissue disease characterized by specific inflammatory lesions in muscle biopsy. It is caused by vasculitis determined by humoral factors with subsequent inflammatory cell accumulation, mainly T CD4+ and B cells, which infiltrate myocytes leading to its vacuolization and degeneration (mainly in the skeletal muscles, rarely in the smooth muscles). The incidence of DM is estimated at 1-10 per million in adults and at 1-3.

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Unlabelled: IFN-gamma a potent antifibrotic activity in interstitial lung diseases (ILD). T cells, both Th1 and Tc1, are considered to be the main local source of IFN-gamma.

Material And Methods: BAL fluids of 98 patients with ILD, incl.

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Cigarette smoking enhances apoptosis rate of alveolar macrophages. However, little is known about the appearance and extension of apoptosis in bronchoalveolar lavage (BAL) lymphocytes originating from smoker individuals, both in pulmonary sarcoidosis (the disease characterized by lymphocytic alveolitis) and in controls. BAL was carried out in 60 nontreated patients with pulmonary sarcoidosis, subdivided acc.

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Lymphangioleiomyomatosis [LAM] is a rare lung disease affecting women and characterized by abnormal smooth muscle cells (LAM cells) proliferation along lung and lymphatic channels. The frequent occurrence of extrapulmonary LAM [e-LAM] has been reported as abdomen pelvic lymph nodes involvement, angiomyolipomas, lymphangioleiomyomas or lymphangiomas in LAM patients. An extrapulmonary manifestation as the initial LAM presentation preceding pulmonary disorders and as asymptomatic extrapulmonary LAM lesions are unusual.

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