Synthesis, photophysical characterisation, quantum-chemical study and antiproliferative activity of cyclometalated Ir(III) complexes based on 3,5-dimethyl-1-phenyl-1-pyrazole and N,N-donor ligands.

In this paper, we present the synthesis of four new complexes: the dimeric precursor [Ir(dmppz)(-Cl)] (1) (Hdmppz - 3,5-dimethyl-1-phenyl-1-pyrazole) and heteroleptic bis-cyclometalated complexes: [Ir(dmppz)(PyCO)]PF·½CHCl (2), [Ir(dmppz)(Hbiim)]PF·HO (3), and [Ir(dmppz)(PyBIm)]PF (4), with auxiliary N,N-donor ligands: 2-di(pyridyl)ketone (PyCO), 2,2'-biimidazole (Hbiim) and 2-(2'-pyridyl)benzimidazole (PyBIm). In the obtained complexes, SC-X-ray analysis revealed that Ir(III) has an octahedral coordination sphere with chromophores of the type {IrNCCl} (1) or {IrNC} (2-4). The complexes obtained, which have been fully characterised by physicochemical methods (CHN, TG, FTIR, UV-Vis, PL and H, C, N NMR), were used to continue our studies on the factors influencing the cytotoxic properties of potential chemotherapeutic agents ().

Ruthenium(II) and Iridium(III) Complexes as Tested Materials for New Anticancer Agents.

The oncological use of cisplatin is hindered by its severe side effects and a very important resistance problem. To overcome these problems, scientists have attempted to design new generation transition-metal anticancer complexes. In this study, we present new complexes, ruthenium(II) [(η--cymene)RuCl(pyCO)]PF (), iridium(III) [(η-Cp)IrCl(pyCO)]PF (), and NH[IrCl(pyCO)]·HO (), based on di-2-pyridylketone (pyCO).

Similarities and differences in d low-spin ruthenium, rhodium and iridium half-sandwich complexes: synthesis, structure, cytotoxicity and interaction with biological targets.

In this paper, we discussed the similarities and differences in d low-spin half-sandwich ruthenium, rhodium and iridium complexes containing 2,2'-biimidazole (Hbiim). Three new complexes, {[RuCl(Hbiim)(η-p-cymene)]PF}·HO (1), [(η-Cp)RhCl(Hbiim)]PF (2), and [(η-Cp)IrCl(Hbiim)]PF (3), were fully characterized by CHN, X-ray diffraction analysis, UV-Vis, FTIR, and H, C and N NMR spectroscopies. The complexes exhibit a typical pseudooctahedral piano-stool geometry, in which the aromatic arene ring (p-cymene or Cp) forms the seat, while the bidentate 2,2'-biimidazole and chloride ion form the three legs of the piano stool.