Publications by authors named "Agnieszka Czarnocka-Cieciura"
Article Synopsis
- Complete deadenylation of polyA-tails in mRNAs is crucial for starting the decapping and degradation processes in cells.
- Researchers conducted RNA sequencing in yeast and created a model estimating the rate of deadenylation, finding it to be about 10 adenines per minute.
- The study revealed that while degradation rates of specific mRNAs, like ribosomal protein-coding mRNAs, increase under stress, these mRNAs can still degrade even if their deadenylation is inhibited, highlighting complex interactions between these processes.
Cytoplasmic polyadenylation plays a vital role in gametogenesis; however, the participating enzymes and substrates in mammals remain unclear. Using knockout and knock-in mouse models, we describe the essential role of four TENT5 poly(A) polymerases in mouse fertility and gametogenesis. TENT5B and TENT5C play crucial yet redundant roles in oogenesis, with the double knockout of both genes leading to oocyte degeneration.
View Article and Find Full Text PDFRibosomes are macromolecular complexes responsible for translation. During last few years our understanding of their role in the cell was changed. Discoveries showing their variability in the protein composition and rRNA sequence suggested that they can play an active role in the gene regulation, selecting mRNA molecules to be translated and affecting the shape of the proteome.
View Article and Find Full Text PDF