New Markers of Inflammation and Tubular Damage in Children with Chronic Kidney Disease.

Introduction And Aims: Monocyte chemoattractant protein- (MCP-) 1, macrophage colony-stimulating factor (MCSF), and neopterin are connected with monocyte migration and transition into macrophages, leading to fibrosis and tubular damage in the course of CKD. The aim of the study was to analyze the applicability of urinary fractional excretion (FE) of MCP1, MCSF, and neopterin, as markers of inflammation and tubular damage, in children with CKD.

Methods: The study group consisted of 61 children with CKD stages 1-5 and 23 age-matched controls.

Epidermal growth factor, growth differentiation factor-15, and survivin as novel biocompatibility markers in children on chronic dialysis.

Context: Chronic dialysis results in aggravation of apoptosis and cell damage, triggered by bioincompatibility of dialysis membranes and peritoneal fluids.

Objective: The aim of study was to assess the usefulness of epidermal growth factor (EGF), growth differentiation factor (GDF)-15, and survivin as novel markers of biocompatibility in dialyzed children.

Materials And Methods: Parameters were assessed by ELISA in 19 patients on hemodialysis and 22 children on peritoneal dialysis.

Urine survivin, E-cadherin and matrix metalloproteinases as novel biomarkers in children with chronic kidney disease.

Context: Epithelial-mesenchymal transition (EMT) leads to renal fibrosis and chronic kidney disease (CKD).

Objective: The aim of this study was to assess the usefulness of survivin, E-cadherin and metalloproteinases (MMPs) as biomarkers of CKD-related complications.

Material And Methods: Survivin, E-cadherin, MMP-2, MMP-9 and TGFbeta1 were assessed by ELISA in 41 children with CKD stages 3 to 5 and in 23 controls.

Urine matrix metalloproteinases and their extracellular inducer EMMPRIN in children with chronic kidney disease.

Background: Transforming growth factor (TGF)beta1 and matrix metalloproteinases (MMPs) play an essential role in CKD-related tissue remodeling. However, there are no data on urine MMPs and their extracellular inducer EMMPRIN in CKD patients. The aim of study was to assess the concentrations of MMP-2, MMP-7, MMP-9, EMMPRIN and TGFbeta1 in serum and urine of CKD children and to analyze the potential relations between those parameters.

Subclinical hypothyroidism as a rare cofactor in chronic kidney disease (CKD) - related anemia.

Background: Both chronic kidney disease (CKD) and hypothyroidism may cause anemia. However, the combination of the three above-mentioned phenomena in children has not been described yet.

Methods: Our aim was to present a case of a 16-year-old girl hospitalized due to the renal impairment in the course of chemotherapy.