Publications by authors named "Agnethe M Ahnfeldt"
Background: Human milk for very preterm infants need fortification for optimal growth and development but the optimal fortification product remains to be identified.
Aims: To investigate feasibility, safety and preliminary efficacy on growth and blood biochemistry when using intact bovine colostrum (BC) as a fortifier to human milk in very preterm infants.
Methods: In an open-label, multicenter, randomized controlled pilot trial (infants 26-31 weeks' gestation), mother's own milk or donor human milk was fortified with powdered BC (n = 115) or a conventional fortifier (CF, bovine-milk-based, n = 117) until 35 weeks' postmenstrual age.
Article Synopsis
- - Atrial standstill (AS) is a rare condition marked by lack of electrical activity in the heart's atria, and this study aims to explore its clinical features, genetic causes, and patient outcomes.
- - The research involved 20 patients diagnosed with AS at an average age of 6.6 years, revealing a high prevalence of arrhythmias (80%) and significant cardiac events, including cardiac arrests in 4 patients.
- - Genetic testing showed SCN5A variants in 65% of patients, indicating that these variants may contribute to AS; patients unable to pace their atria face increased risks for blood clots, emphasizing the need for anticoagulant treatment.
Background: Human milk does not meet the nutritional needs to support optimal growth of very preterm infants during the first weeks of life. Nutrient fortifiers are therefore added to human milk, though these products are suspected to increase gut dysmotility. The objective was to evaluate whether fortification with bovine colostrum (BC) improves bowel habits compared to a conventional fortifier (CF) in very preterm infants.
View Article and Find Full Text PDFBackground: Extrauterine growth restriction (EUGR) in preterm infants is associated with higher morbidity and impaired neurodevelopment. Early nutrition support may prevent EUGR in preterm infants, but it is not known if this improves organ development and brain function in the short and long term.
Objective: Using pigs as models for infants, we hypothesized that diet-induced EUGR impairs gut, immunity, and brain development in preterm neonates during the first weeks after birth.
Human milk is rich in nutritional factors, such as alpha-lactalbumin (α-Lac), and important for neonatal development, but nutrient supplementation may be required for optimal growth. Using a pig model, we hypothesized that α-Lac-enriched whey protein concentrate (WPC) supplementation improves neonatal development. Cesarean-delivered preterm pigs were fed either dilute bovine milk (REF) or REF milk supplemented with WPC with normal (STANDARD-ALPHA) or high (HIGH-ALPHA) α-Lac.
View Article and Find Full Text PDFArticle Synopsis
- Very preterm infants need extra nutrients for growth because their milk might not have enough.
- Researchers are testing two types of milk fortifiers: one made from bovine colostrum and another made from regular bovine milk, to see which is better for the babies.
- The study will look at how well the infants grow and whether either milk fortifier causes any health issues like stomach problems or infections.
Atrial standstill is a rare arrhythmia defined by the absence of mechanical and electrical activity in the atria. Few cases of atrial standstill have been described in children, none of which have presented with cerebral infarction confirmed by imaging. We report a unique case of a 7-year-old girl presenting with expressive aphasia, central facial palsy and irregular pulse with cerebral infarction secondary to atrial standstill.
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