Publications by authors named "Agnes Reisenauer"
Article Synopsis
- The study investigates how valproic acid (VPA) affects human cytomegalovirus (HCMV) replication in retinal pigment epithelial (RPE) cells, revealing that VPA concentrations less than or equal to 1 mM can increase HCMV antigen expression and replication significantly.
- Results show that VPA enhances HCMV replication through the inhibition of histone deacetylase (HDAC) and also activates Erk 1/2 phosphorylation without depending on it.
- The findings suggest that patients at risk for HCMV retinitis receiving VPA or other HDAC inhibitors need close monitoring due to the potential risk of increased virus replication.